PMID- 21515866 OWN - NLM STAT- MEDLINE DCOM- 20110811 LR - 20190101 IS - 1535-2900 (Electronic) IS - 1079-2082 (Linking) VI - 68 IP - 9 DP - 2011 May 1 TI - Efficacy and safety of 30-minute infusions of conivaptan in euvolemic and hypervolemic hyponatremia. PG - 818-27 LID - 10.2146/ajhp100260 [doi] AB - PURPOSE: The efficacy and safety of conivaptan administered via 30-minute i.v. infusion to patients with euvolemic or hypervolemic hyponatremia were evaluated. METHODS: Hospitalized adults with a baseline serum sodium concentration (SSC) of 115-130 meq/L and euvolemia or hypervolemia on clinical evaluation were randomized to receive conivaptan hydrochloride 20 mg once or twice daily or placebo via 30-minute i.v. infusion. The primary efficacy measure was the change in SSC from baseline to 48 hours. RESULTS: A total of 49 patients received one of the three treatment regimens. Conivaptan once and twice daily produced significant least-squares mean changes from baseline in SSC at 48 hours of 3.46 meq/L (95% confidence interval [CI], 1.75-5.18 meq/L) and 6.22 meq/L (95% CI, 4.34-8.10 meq/L), respectively (p = 0.028 between conivaptan-treated groups). These changes were significantly greater compared with those in the placebo group at hour 4 (p = 0.049) and at all time points onward of hour 28 (p