PMID- 21516074
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20151119
IS  - 0026-4725 (Print)
IS  - 0026-4725 (Linking)
VI  - 59
IP  - 3
DP  - 2011 Jun
TI  - Clinical applicability of coronary atherosclerotic lesion characterization.
PG  - 255-70
AB  - Native coronary atherosclerosis (CAS) is a diffuse and progressive disease 
      process that is occasionally associated with either clinical atherothrombosis 
      and/or major adverse cardiac events (MACE) including: ST elevation myocardial 
      infarction (STEMI), acute coronary syndromes without ST elevation (ACSWSTE), 
      heart failure, cardiac arrest and sudden cardiac death. Both, the timing and 
      coronary site responsible for the MACE are currently unpredictable. 
      Cardiovascular investigators have engaged in the task of characterizing CAS 
      lesions in order to enhance our knowledge of CAS pathophysiology. It was expected 
      that the knowledge acquired will allow scientists and clinicians to develop 
      effective strategies to detect and treat "vulnerable plaque" (VP) prior to the 
      evolution of MACE. This review discusses the emerging data regarding the 
      pathology and natural history of the VP and vulnerable patient and the progress 
      made in characterizing atherosclerotic plaque instability and vulnerability. 
      Future directions in the field of plaque characterization and their potential 
      clinical and research applications are discussed.
FAU - Kaluski, E
AU  - Kaluski E
AD  - Division of Cardiology, Department of Medicine, University Hospital and New 
      Jersey Medical School, Newark, NJ, USA. kalusked@umdnj.edu
FAU - Waller, A
AU  - Waller A
FAU - Patel, A
AU  - Patel A
FAU - Gerula, C
AU  - Gerula C
FAU - Maher, J
AU  - Maher J
FAU - Haider, B
AU  - Haider B
FAU - Klapholz, M
AU  - Klapholz M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Cardioangiol
JT  - Minerva cardioangiologica
JID - 0400725
RN  - 0 (Biomarkers)
SB  - IM
MH  - Acute Coronary Syndrome/pathology
MH  - Biomarkers/blood
MH  - Clinical Trials as Topic
MH  - Coronary Artery Disease/diagnosis/mortality/*pathology/physiopathology/therapy
MH  - Death, Sudden, Cardiac/pathology
MH  - Disease Progression
MH  - Evidence-Based Medicine
MH  - Heart Arrest/pathology
MH  - Heart Conduction System/physiopathology
MH  - Heart Failure/pathology
MH  - Humans
MH  - Myocardial Infarction/pathology
MH  - Plaque, Atherosclerotic/*pathology
MH  - Risk Assessment
MH  - Severity of Illness Index
EDAT- 2011/04/26 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - R05113080 [pii]
PST - ppublish
SO  - Minerva Cardioangiol. 2011 Jun;59(3):255-70.