PMID- 21518165
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20110912
IS  - 1600-0854 (Electronic)
IS  - 1398-9219 (Linking)
VI  - 12
IP  - 10
DP  - 2011 Oct
TI  - ESCRT proteins and cell signalling.
PG  - 1291-7
LID - 10.1111/j.1600-0854.2011.01210.x [doi]
AB  - Subunits of the endosomal sorting complex required for transport (ESCRT) were 
      identified as components of a molecular machinery that sorts ubiquitinated 
      membrane proteins into the intraluminal vesicles (ILVs) of multivesicular 
      endosomes (MVEs) for subsequent delivery to the lumen of lysosomes or related 
      organelles. As many of the membrane proteins that undergo ESCRT-mediated sorting 
      are signalling receptors that are ubiquitinated in response to ligand binding, 
      ESCRT subunits have been hypothesized to play a crucial role in attenuation of 
      cell signalling by mediating ligand-induced receptor degradation. Here we discuss 
      this concept based on the examples from loss-of-function studies in model 
      organisms and cell lines. The emerging picture is that ESCRTs are indeed involved 
      in downregulation of receptor signalling pathways associated with cell survival, 
      proliferation and polarity. In addition, the recent discovery of a positive role 
      for the ESCRT pathway in Wnt signalling through sequestration of an inhibitory 
      cytosolic component into MVEs illustrates that ESCRTs may also control signalling 
      in ways that are independent of degradative receptor sorting.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Wegner, Catherine Sem
AU  - Wegner CS
AD  - Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, 
      Montebello, Oslo 0310, Norway.
FAU - Rodahl, Lina M W
AU  - Rodahl LM
FAU - Stenmark, Harald
AU  - Stenmark H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110513
PL  - England
TA  - Traffic
JT  - Traffic (Copenhagen, Denmark)
JID - 100939340
RN  - 0 (Endosomal Sorting Complexes Required for Transport)
RN  - 0 (Protein Subunits)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Cell Survival/physiology
MH  - Endocytosis/physiology
MH  - Endosomal Sorting Complexes Required for Transport/genetics/*metabolism
MH  - Endosomes/*metabolism
MH  - Humans
MH  - Protein Subunits
MH  - Signal Transduction/*physiology
EDAT- 2011/04/27 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1111/j.1600-0854.2011.01210.x [doi]
PST - ppublish
SO  - Traffic. 2011 Oct;12(10):1291-7. doi: 10.1111/j.1600-0854.2011.01210.x. Epub 2011 
      May 13.