PMID- 21518573
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110426
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 124
IP  - 5
DP  - 2011 Mar
TI  - Antibodies against major histocompatibility complex class I-related chain A in 
      transplant recipients.
PG  - 764-70
AB  - OBJECTIVE: To review the role of polymorphism of major histocompatibility complex 
      class I-related chain A (MICA) gene and antibodies against MICA antigens in 
      transplant immunology. DATA SOURCES: The data used in this review were mainly 
      from our own results and from the relevant English language literatures published 
      from 1999 to 2010. Some data presented in this review are in press. STUDY 
      SELECTION: Articles regarding MICA gene discovery and pioneering finding of 
      antibodies against MICA antigen and allograft rejection were selected. This 
      review chronicles the development of our understanding of the role that MICA 
      antigens and antibodies may play in organ transplantation. RESULTS: Polymorphic 
      glycoprotein MICA antigens were detected on freshly isolated human umbilical cord 
      endothelial cells, but not on peripheral lymphocytes. Antibodies were found and 
      typing of recipients and donors by sequencing the MICA alleles has established 
      that de novo antibodies produced in kidney transplant recipients are directed at 
      mismatched MICA epitopes and are associated with acute rejection and chronic 
      transplant failure. The specificity of antibodies against the epitopes of MICA 
      antigens were well characterized by donor MICA typing, single antigen array 
      testing with antibody absorption and elution. Acute graft-versus-host disease was 
      observed in stem-cell recipients who were mismatched for MICA. CONCLUSIONS: 
      Immunization against mismatched MICA epitopes encountered in donor organs after 
      transplantation may result in antibodies against MICA alleles. Testing for MICA 
      donor-specific antibodies (DSA) which are associated with early failure of kidney 
      transplants may be helpful for identifying some of the targets of antibodies 
      against antigens other than the human leukocyte antigen (HLA) and for improving 
      transplantation outcome.
FAU - Zou, Yizhou
AU  - Zou Y
AD  - Transplantation Immunology Division, Department of Internal Medicine, University 
      of Texas Southwestern Medical Center, USA.
FAU - Stastny, Peter
AU  - Stastny P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Antibodies)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Antibodies/*immunology
MH  - Graft Rejection/immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Organ Transplantation
EDAT- 2011/04/27 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2011 Mar;124(5):764-70.