PMID- 21519548
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2093-3673 (Electronic)
IS  - 2093-3665 (Print)
IS  - 2093-3665 (Linking)
VI  - 44
IP  - 1
DP  - 2011 Mar
TI  - Transient lysosomal activation is essential for p75 nerve growth factor receptor 
      expression in myelinated Schwann cells during Wallerian degeneration.
PG  - 41-9
LID - 10.5115/acb.2011.44.1.41 [doi]
AB  - Myelinated Schwann cells in the peripheral nervous system express the p75 nerve 
      growth factor receptor (p75NGFR) as a consequence of Schwann cell 
      dedifferentiation during Wallerian degeneration. p75NGFR has been implicated in 
      the remyelination of regenerating nerves. Although many studies have shown 
      various mechanisms underlying Schwann cell dedifferentiation, the molecular 
      mechanism contributing to the re-expression of p75NGFR in differentiated Schwann 
      cells is largely unknown. In the present study, we found that lysosomes were 
      transiently activated in Schwann cells after nerve injury and that the inhibition 
      of lysosomal activation by chloroquine or lysosomal acidification inhibitors 
      prevented p75NGFR expression at the mRNA transcriptional level in an ex vivo 
      Wallerian degeneration model. Lysosomal acidification inhibitors suppressed 
      demyelination, but not axonal degeneration, thereby suggesting that demyelination 
      mediated by lysosomes may be an important signal for inducing p75NGFR expression. 
      Tumor necrosis factor-alpha (TNF-alpha) has been suggested to be involved in regulating 
      p75NGFR expression in Schwann cells. In this study, we found that removing TNF-alpha 
      in vivo did not significantly suppress the induction of both lysosomes and 
      p75NGFR. Thus, these findings suggest that lysosomal activation is tightly 
      correlated with the induction of p75NGFR in demyelinating Schwann cells during 
      Wallerian degeneration.
FAU - Jung, Junyang
AU  - Jung J
AD  - Department of Physiology, Mitochondria Hub Research Center, College of Medicine, 
      Dong-A University, Busan, Korea.
FAU - Cai, Wenting
AU  - Cai W
FAU - Jang, So Young
AU  - Jang SY
FAU - Shin, Yoon Kyoung
AU  - Shin YK
FAU - Suh, Duk Joon
AU  - Suh DJ
FAU - Kim, Jong Kuk
AU  - Kim JK
FAU - Park, Hwan Tae
AU  - Park HT
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - Korea (South)
TA  - Anat Cell Biol
JT  - Anatomy & cell biology
JID - 101531987
PMC - PMC3080007
OTO - NOTNLM
OT  - Demyelination
OT  - Lysosomes
OT  - Schwann cells
OT  - Wallerian degeneration
OT  - p75NGFR
EDAT- 2011/04/27 06:00
MHDA- 2011/04/27 06:01
PMCR- 2011/03/01
CRDT- 2011/04/27 06:00
PHST- 2011/01/28 00:00 [received]
PHST- 2011/03/03 00:00 [revised]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/04/27 06:01 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - 10.5115/acb.2011.44.1.41 [doi]
PST - ppublish
SO  - Anat Cell Biol. 2011 Mar;44(1):41-9. doi: 10.5115/acb.2011.44.1.41. Epub 2011 Mar 
      31.