PMID- 21521415
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110427
IS  - 1469-0691 (Electronic)
IS  - 1198-743X (Linking)
VI  - 17
IP  - 5
DP  - 2011 May
TI  - Expression of matrix metalloproteinases and their tissue inhibitors in the serum 
      and cerebrospinal fluid of patients with meningitis.
PG  - 780-4
LID - 10.1111/j.1469-0691.2010.03393.x [doi]
AB  - Meningitis is associated with an imbalance between matrix metalloproteinases 
      (MMPs) and endogenous tissue inhibitors of MMP (TIMPs). Serum and CSF were 
      collected prospectively from all patients with meningitis between January 2008 
      and December 2008 to measure the concentrations of MMP/TIMP in those patients who 
      underwent a lumbar puncture for a presumptive diagnosis of meningitis. A total of 
      199 patients were enrolled into the study. The concentrations of CSF MMP-9 and 
      TIMP-1 were significantly higher in the meningitis group compared with the 
      control group (p 0.032 and p <0.001, respectively). However, the CSF TIMP-4 
      levels were significantly lower in the meningitis groups compared with the 
      control groups (p <0.001). Patients with bacterial meningitis had higher CSF 
      MMP-9 and TIMP-1 levels than those who had aseptic meningitis and controls. 
      Patients with various infectious meningitis etiologies tended to have higher CSF 
      MMP-9 expression by gelatin zymography when compared with the controls. In 
      conclusion, MMP/TIMP system dysregulation was found in patients with meningitis, 
      and CSF MMP and TIMP might act as novel indicators in patients with meningitis.
CI  - (c) 2010 The Authors. Clinical Microbiology and Infection (c) 2010 European Society 
      of Clinical Microbiology and Infectious Diseases.
FAU - Tsai, H-C
AU  - Tsai HC
AD  - Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans 
      General Hospital, Kaohsiung City, Taiwan, Republic of China.
FAU - Shi, M-H
AU  - Shi MH
FAU - Lee, S S-J
AU  - Lee SS
FAU - Wann, S-R
AU  - Wann SR
FAU - Tai, M-H
AU  - Tai MH
FAU - Chen, Y-S
AU  - Chen YS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101203
PL  - England
TA  - Clin Microbiol Infect
JT  - Clinical microbiology and infection : the official publication of the European 
      Society of Clinical Microbiology and Infectious Diseases
JID - 9516420
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Humans
MH  - Matrix Metalloproteinases/*blood/*cerebrospinal fluid
MH  - Meningitis/diagnosis/*enzymology
MH  - Prospective Studies
MH  - Tissue Inhibitor of Metalloproteinases/*blood/*cerebrospinal fluid
EDAT- 2011/04/28 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S1198-743X(15)60276-2 [pii]
AID - 10.1111/j.1469-0691.2010.03393.x [doi]
PST - ppublish
SO  - Clin Microbiol Infect. 2011 May;17(5):780-4. doi: 
      10.1111/j.1469-0691.2010.03393.x. Epub 2010 Dec 3.