PMID- 21521647
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20211020
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 61
IP  - 1-2
DP  - 2011 Jul-Aug
TI  - Differential effects of cocaine and MDMA self-administration on cortical 
      serotonin transporter availability in monkeys.
PG  - 245-51
LID - 10.1016/j.neuropharm.2011.04.007 [doi]
AB  - Cocaine self-administration alters brain dopaminergic and serotonergic function 
      primarily in mesolimbic and prefrontal brain regions whereas 
      3,4-methylenedioxymethamphetamine (MDMA) self-administration predominately alters 
      brain serotonergic function in a more widespread distribution across cortical 
      regions. We previously reported that, compared to drug-naive rhesus monkeys, 
      self-administration of cocaine but not MDMA was associated with increased 
      serotonin transporter (SERT) availability in two mesolimbic regions, the caudate 
      nucleus and putamen, as measured by positron emission tomography (PET) using the 
      SERT-specific ligand 
      [(11)C]-3-amino-4(2-dimethylamino-methyl-phenylsulfanyl)-benzonitrile 
      ([(11)C]DASB). The goal of the present study was to extend this comparison 
      between cocaine and MDMA self-administration to SERT availability in cortical 
      regions, which have been shown previously to be affected in human drug abusers 
      and are associated with executive function. PET studies using [(11)C]DASB were 
      conducted in adult male rhesus monkeys with a history of cocaine (mean 
      intake = 742.6 mg/kg) or MDMA (mean intake = 121.0 mg/kg) self-administration, 
      and drug-naive controls (n = 4/group). Regions of interest were drawn for several 
      cortical (prefrontal, temporal, parietal, occipital and midcingulate) and 
      subcortical (thalamus, amygdala and hippocampus) areas. Cortical SERT 
      availability was significantly higher in monkeys with a cocaine 
      self-administration history compared to controls whereas MDMA self-administration 
      resulted in lower levels of SERT availability. These data extend our previous 
      findings indicating that cocaine and MDMA self-administration differentially 
      alter SERT availability in subcortical and cortical regions, which may have 
      implications for development of treatment drugs.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Gould, Robert W
AU  - Gould RW
AD  - Department of Physiology and Pharmacology, Wake Forest University School of 
      Medicine, Winston-Salem, NC 27157, United States.
FAU - Gage, H Donald
AU  - Gage HD
FAU - Banks, Matthew L
AU  - Banks ML
FAU - Blaylock, Brandi L
AU  - Blaylock BL
FAU - Czoty, Paul W
AU  - Czoty PW
FAU - Nader, Michael A
AU  - Nader MA
LA  - eng
GR  - DA-06634/DA/NIDA NIH HHS/United States
GR  - R01 DA010584/DA/NIDA NIH HHS/United States
GR  - DA-020281/DA/NIDA NIH HHS/United States
GR  - R01 DA025120-04/DA/NIDA NIH HHS/United States
GR  - R01 DA014637/DA/NIDA NIH HHS/United States
GR  - DA-025120/DA/NIDA NIH HHS/United States
GR  - R01 DA025120/DA/NIDA NIH HHS/United States
GR  - R37 DA010584-15/DA/NIDA NIH HHS/United States
GR  - R37 DA010584/DA/NIDA NIH HHS/United States
GR  - DA-10584/DA/NIDA NIH HHS/United States
GR  - F31 DA020281/DA/NIDA NIH HHS/United States
GR  - R01 DA014637-05/DA/NIDA NIH HHS/United States
GR  - P50 DA006634/DA/NIDA NIH HHS/United States
GR  - DA-14637/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110417
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cerebral Cortex/diagnostic imaging/*drug effects/*metabolism
MH  - Cocaine/*administration & dosage
MH  - Haplorhini
MH  - Macaca mulatta
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Positron-Emission Tomography/methods
MH  - Self Administration
MH  - Serotonin Plasma Membrane Transport Proteins/*metabolism
PMC - PMC3105184
MID - NIHMS293994
EDAT- 2011/04/28 06:00
MHDA- 2012/04/18 06:00
PMCR- 2012/07/01
CRDT- 2011/04/28 06:00
PHST- 2011/01/28 00:00 [received]
PHST- 2011/04/04 00:00 [revised]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - S0028-3908(11)00152-3 [pii]
AID - 10.1016/j.neuropharm.2011.04.007 [doi]
PST - ppublish
SO  - Neuropharmacology. 2011 Jul-Aug;61(1-2):245-51. doi: 
      10.1016/j.neuropharm.2011.04.007. Epub 2011 Apr 17.