PMID- 21523219
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2000-2297 (Electronic)
IS  - 2000-2297 (Linking)
VI  - 2
DP  - 2010 Dec 21
TI  - Porphyromonas gingivalis-dendritic cell interactions: consequences for coronary 
      artery disease.
LID - 10.3402/jom.v2i0.5782 [doi]
AB  - An estimated 80 million US adults have one or more types of cardiovascular 
      diseases. Atherosclerosis is the single most important contributor to 
      cardiovascular diseases; however, only 50% of atherosclerosis patients have 
      currently identified risk factors. Chronic periodontitis, a common inflammatory 
      disease, is linked to an increased cardiovascular risk. Dendritic cells (DCs) are 
      potent antigen presenting cells that infiltrate arterial walls and may 
      destabilize atherosclerotic plaques in cardiovascular disease. While the source 
      of these DCs in atherosclerotic plaques is presently unclear, we propose that 
      dermal DCs from peripheral inflamed sites such as CP tissues are a potential 
      source. This review will examine the role of the opportunistic oral pathogen 
      Porphyromonas gingivalis in invading DCs and stimulating their mobilization and 
      misdirection through the bloodstream. Based on our published observations, 
      combined with some new data, as well as a focused review of the literature we 
      will propose a model for how P. gingivalis may exploit DCs to gain access to 
      systemic circulation and contribute to coronary artery disease. Our published 
      evidence supports a significant role for P. gingivalis in subverting normal DC 
      function, promoting a semimature, highly migratory, and immunosuppressive DC 
      phenotype that contributes to the inflammatory development of atherosclerosis 
      and, eventually, plaque rupture.
FAU - Zeituni, Amir E
AU  - Zeituni AE
AD  - Department of Molecular Genetics and Microbiology, Center for Infectious 
      Diseases, Stony Brook University, Stony Brook, NY, USA.
FAU - Carrion, Julio
AU  - Carrion J
FAU - Cutler, Christopher W
AU  - Cutler CW
LA  - eng
GR  - R01 DE014328-07S1/DE/NIDCR NIH HHS/United States
GR  - R01 DE014328/DE/NIDCR NIH HHS/United States
GR  - R21 DE020916/DE/NIDCR NIH HHS/United States
GR  - R01 DE014328-10/DE/NIDCR NIH HHS/United States
GR  - R01 DE014328-08/DE/NIDCR NIH HHS/United States
GR  - R01 DE014328-09/DE/NIDCR NIH HHS/United States
PT  - Journal Article
DEP - 20101221
PL  - United States
TA  - J Oral Microbiol
JT  - Journal of oral microbiology
JID - 101551049
PMC - PMC3084565
OTO - NOTNLM
OT  - DC-SIGN
OT  - Porphyromonas gingivalis
OT  - atherosclerosis
OT  - dendritic cells
OT  - periodontitis
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2010/01/01
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - JOM-2-5782 [pii]
AID - 10.3402/jom.v2i0.5782 [doi]
PST - epublish
SO  - J Oral Microbiol. 2010 Dec 21;2. doi: 10.3402/jom.v2i0.5782.