PMID- 21523954
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 10
IP  - 8
DP  - 2001 Apr 1
TI  - Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate 
      region.
PG  - 891-99
AB  - Asthma is a common, complex human disease. Gene discovery in asthma has been 
      complicated by substantial etiological heterogeneity, the possibility of genes of 
      small effect and the concomitant requirement for large sample sizes. Linkage to 
      asthma phenotypes has been investigated most intensively in the 5q chromosomal 
      region, although results have been inconsistent across studies and all studies 
      have had modest sample sizes. One potential solution to these issues is to 
      combine data from multiple studies in a retrospective meta-analysis by pooling 
      either summary statistics or raw data. The International Consortium on Asthma 
      Genetics combined data from 11 data sets (n = 6277 subjects) to investigate 
      evidence for linkage of 35 markers spanning the cytokine cluster on chromosome 
      5q31-33 to 'asthma' dichotomy and total serum immunoglobulin E (IgE) levels. 
      Chromosome 5q markers typed in different centers were integrated into a consensus 
      map to facilitate effective data pooling. Multipoint linkage analyses using a new 
      Haseman-Elston method were performed with all data sets pooled together, and also 
      separately with the resulting linkage statistics pooled by meta-analytic methods. 
      Our results did not provide any evidence significant at the 5% level that loci 
      conferring susceptibility to asthma or atopy are present in the 5q31-33 region; 
      however, there was some weak evidence (empirical P = 0.077) of linkage to asthma 
      affection. This study suggests that loci in 5q31-33 have at most a modest effect 
      on susceptibility to asthma or total serum IgE levels, may not be detectable or 
      present in all human populations and are difficult to detect even using combined 
      linkage evidence from 2400-2600 full sibling pairs.
FAU - Palmer, L J
AU  - Palmer LJ
AD  - Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, 
      Harvard University, Boston, MA 02115, USA. reljp@channing.harvard.edu
FAU - Barnes, K C
AU  - Barnes KC
FAU - Burton, P R
AU  - Burton PR
FAU - Chen, H
AU  - Chen H
FAU - Cookson, W O
AU  - Cookson WO
CN  - Collaborative Study on the Genetics of Asthma
FAU - Deichmann, K A
AU  - Deichmann KA
FAU - Elston, R C
AU  - Elston RC
FAU - Holloway, J W
AU  - Holloway JW
FAU - Jacobs, K B
AU  - Jacobs KB
FAU - Laitinen, T
AU  - Laitinen T
FAU - Wjst, M
AU  - Wjst M
LA  - eng
GR  - 1 P41 RR03655/RR/NCRR NIH HHS/United States
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/blood/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 5/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Linkage
MH  - Genetic Predisposition to Disease/genetics
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Young Adult
FIR - Beaty, T
IR  - Beaty T
FIR - Bleecker, E
IR  - Bleecker E
FIR - Blumenthal, M
IR  - Blumenthal M
FIR - Ober, C
IR  - Ober C
FIR - Rich, S
IR  - Rich S
EDAT- 2001/04/01 00:00
MHDA- 2011/05/10 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2001/04/01 00:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - 10.1093/hmg/10.8.891 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2001 Apr 1;10(8):891-99. doi: 10.1093/hmg/10.8.891.