PMID- 21524761
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20181201
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 137
IP  - 7
DP  - 2011 Sep 17
TI  - [Comparative performance of QuantiFERON((R))-TB Gold IT versus tuberculin skin test 
      among contact investigations for latent tuberculosis infection].
PG  - 289-96
LID - 10.1016/j.medcli.2010.11.036 [doi]
AB  - BACKGROUND AND OBJECTIVE: Until recently, the only tool for detection of latent 
      tuberculosis infection (LTI) was the tuberculin skin test (PPD). 
      QuantiFERON((R))-TB Gold In-Tube (QF), as well as other Mycobacterium 
      tuberculosis-specific interferon-gamma release assays (IGRAs), appears to be an 
      alternative or adjunct to the PPD. The goal of the study was to compare QF with 
      PPD to evaluate de accuracy of QF for routinely identifying LTI in contact 
      investigations. PATIENTS AND METHOD: We performed a descriptive and prospective 
      study with contacts of culture-confirmed tuberculosis source cases in Bizkaia and 
      Araba from May 2007 through February 2008 who underwent QF and PPD. Concordance 
      between both tests was analyzed using the kappa statistic (kappa). RESULTS: 376 
      contacts were found: 8 were high-risk children (age < 15), 30 low-medium risk 
      children, 46 high-risk adults (age>14) and 270 low-medium risk adults. PPD was 
      positive in 160 subjects (42.5%) at PPD >/= 5mm, 141 (37.5%) at PPD >/= 10mm and 95 
      (25.3%) at PPD >/= 15 mm. In QF analysis 94 subjects were positive, 279 negative 
      and 3 indeterminate. Overall agreement between QF and PPD was good at PPD >/= 10mm 
      (kappa=0.53; p<0.0001) but agreement was poor when the index case had positive 
      baciloscopy at PPD >/= 5mm (kappa=0.28; p<0.001) and high-risk contacts at PPD >/= 15 mm 
      (kappa=0.048; p=0.36). CONCLUSIONS: IGRAs are an accurate indicator of LTI, providing 
      a more specific way of diagnostic and reducing the number of subjects to be 
      treated. QF appears to be a valuable public health tool with potential advantages 
      over the PPD and improving resources.
CI  - Copyright (c) 2010 Elsevier Espana, S.L. All rights reserved.
FAU - Delgado Naranjo, Jesus
AU  - Delgado Naranjo J
AD  - Servicio de Medicina Preventiva, Hospital de Cruces, Servicio Vasco de Salud 
      OSAKIDETZA, Baracaldo, Bizkaia, Espana. iosudelgado@orange.es
FAU - Castells Carrillo, Concha
AU  - Castells Carrillo C
FAU - Garcia Calabuig, Miguel Angel
AU  - Garcia Calabuig MA
FAU - Saez Lopez, Inmaculada
AU  - Saez Lopez I
CN  - en representacion del Grupo de Trabajo para el estudio de los IGRAS en Bizkaia y 
      Araba (GTIBA)
LA  - spa
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
TT  - Estudio comparativo de QuantiFERON((R))-TB Gold IT frente a tuberculina para el 
      diagnostico de la infeccion tuberculosa latente en estudios de contactos.
DEP - 20110427
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
RN  - 0 (Antigens, Bacterial)
RN  - 0 (BCG Vaccine)
RN  - 0 (Bacterial Proteins)
RN  - 0 (CFP-10 protein, Mycobacterium tuberculosis)
RN  - 0 (ESAT-6 protein, Mycobacterium tuberculosis)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
CIN - Med Clin (Barc). 2011 Sep 17;137(7):305-7. PMID: 21524771
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, Bacterial/immunology
MH  - BCG Vaccine/immunology
MH  - Bacterial Proteins/immunology
MH  - Child
MH  - Child, Preschool
MH  - Contact Tracing
MH  - *Enzyme-Linked Immunospot Assay
MH  - Female
MH  - Humans
MH  - Infant
MH  - Interferon-gamma/*metabolism
MH  - Latent Tuberculosis/*diagnosis/microbiology
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/isolation & purification
MH  - Prospective Studies
MH  - Risk
MH  - Tuberculin Test
MH  - Vaccination
MH  - Young Adult
FIR - Delgado Naranjo, Jesus
IR  - Delgado Naranjo J
FIR - Castells Carrillo, Concha
IR  - Castells Carrillo C
FIR - Garcia Calabuig, Miguel Angel
IR  - Garcia Calabuig MA
FIR - Saez Lopez, Inmaculada
IR  - Saez Lopez I
FIR - Muniozguren Agirre, Nerea
IR  - Muniozguren Agirre N
FIR - San Jose Rodriguez, Sabino
IR  - San Jose Rodriguez S
FIR - Diez San Vicente, Rosa
IR  - Diez San Vicente R
FIR - Lopez Aranaga, Isabel
IR  - Lopez Aranaga I
FIR - Toja Uriarte, Begona
IR  - Toja Uriarte B
FIR - Santamaria, Maria Isabel
IR  - Santamaria MI
FIR - Salinas Solano, Carlos
IR  - Salinas Solano C
FIR - Garcia Cebrian, Fernando
IR  - Garcia Cebrian F
FIR - Ciruelos Ayuso, Esteban
IR  - Ciruelos Ayuso E
FIR - Ruiz de Gordejuela, Esteban
IR  - Ruiz de Gordejuela E
FIR - Unzaga Baranano, Josebe
IR  - Unzaga Baranano J
FIR - Urra Zalbidegoitia, Elena
IR  - Urra Zalbidegoitia E
FIR - Lopez de Goikoetxea, Maria Jose
IR  - Lopez de Goikoetxea MJ
FIR - Lezaun, Maria Jesus
IR  - Lezaun MJ
FIR - Gomez Perez de Mendiola, Maria del Carmen Rosario
IR  - Gomez Perez de Mendiola Mdel C
EDAT- 2011/04/29 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/04/29 06:00
PHST- 2010/07/28 00:00 [received]
PHST- 2010/11/28 00:00 [revised]
PHST- 2010/11/30 00:00 [accepted]
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S0025-7753(11)00293-4 [pii]
AID - 10.1016/j.medcli.2010.11.036 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2011 Sep 17;137(7):289-96. doi: 10.1016/j.medcli.2010.11.036. 
      Epub 2011 Apr 27.