PMID- 21524944
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20230120
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 879
IP  - 29
DP  - 2011 Nov 1
TI  - D-Aspartate--an important bioactive substance in mammals: a review from an 
      analytical and biological point of view.
PG  - 3108-21
LID - 10.1016/j.jchromb.2011.03.062 [doi]
AB  - It was long believed that D-amino acids were either unnatural isomers or 
      laboratorial artifacts and that the important functions of amino acids were 
      exerted only by l-amino acids. However, recent investigations have shown that a 
      variety of D-amino acids are present in mammals and that they play important 
      roles in physiological functions in the body. Among the free d-amino acids that 
      have been identified in mammals, D-aspartate (D-Asp) has been shown to play a 
      crucial role in the neuroendocrine and endocrine systems as well as in the 
      central nervous system. Here, we present an overview of recent studies of free 
      D-Asp, focusing on the analytical methods in real biological matrices, expression 
      and localization in tissues and cells, biological and physiological activities, 
      biosynthesis, degradation, cellular transport, and possible relevance to disease. 
      In addition to frequently used techniques for the enantiomeric determination of 
      amino acids, including high-performance liquid chromatography and enzymatic 
      methods, the recent development of analytical methods is also described.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Katane, Masumi
AU  - Katane M
AD  - Laboratory of Biomolecular Science, Department of Pharmaceutical Life Sciences, 
      Kitasato University, 5-9-1 Shirokane, Tokyo 108-8641, Japan.
FAU - Homma, Hiroshi
AU  - Homma H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110412
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Chromatography, High Pressure Liquid
MH  - D-Aspartic Acid/*analysis/chemistry/*metabolism
MH  - Humans
MH  - Mammals/*metabolism
MH  - Organ Specificity
MH  - Stereoisomerism
EDAT- 2011/04/29 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/02/01 00:00 [received]
PHST- 2011/03/23 00:00 [revised]
PHST- 2011/03/30 00:00 [accepted]
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - S1570-0232(11)00237-6 [pii]
AID - 10.1016/j.jchromb.2011.03.062 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 1;879(29):3108-21. doi: 
      10.1016/j.jchromb.2011.03.062. Epub 2011 Apr 12.