PMID- 21525816
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20240512
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 17
IP  - 5
DP  - 2011 May
TI  - Use of fondaparinux in a pregnant woman with pulmonary embolism and 
      heparin-induced thrombocytopenia.
PG  - CS56-9
AB  - BACKGROUND: A serious complication of heparin treatment, heparin-induced 
      thrombocytopenia (HIT) is rarely observed in pregnant women. Drug therapy during 
      pregnancy should always be chosen to minimize fetal risk. The management of HIT 
      in pregnancy represents a medical challenge. Unlike heparins, the anticoagulants 
      used in patients with HIT do cross the placenta, with unknown fetal effects. CASE 
      REPORT: We present a case of a 24-year-old female presenting for care at 34 weeks 
      of gestation with acute pulmonary embolism treated initially with unfractionated 
      heparin (UFH) and low molecular weight heparin (LMWH), who developed HIT. She was 
      then successfully treated with fondaparinux. CONCLUSIONS: To the best of our 
      knowledge, this is one of the first case reports describing a successful use of 
      fondaparinux in the treatment of HIT in a third-trimester pregnant woman, 
      providing a novel approach for this subset of patients.
FAU - Ciurzynski, Michal
AU  - Ciurzynski M
AD  - Department of Internal Medicine and Cardiology, Medical University of Warsaw, 
      Warsaw, Poland. michal.ciurzynski@wum.edu.pl
FAU - Jankowski, Krzysztof
AU  - Jankowski K
FAU - Pietrzak, Bronislawa
AU  - Pietrzak B
FAU - Mazanowska, Natalia
AU  - Mazanowska N
FAU - Rzewuska, Ewa
AU  - Rzewuska E
FAU - Kowalik, Robert
AU  - Kowalik R
FAU - Pruszczyk, Piotr
AU  - Pruszczyk P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Polysaccharides)
RN  - 9005-49-6 (Heparin)
RN  - J177FOW5JL (Fondaparinux)
SB  - IM
MH  - Female
MH  - Fondaparinux
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Polysaccharides/administration & dosage/*therapeutic use
MH  - Pregnancy
MH  - Pulmonary Embolism/complications/diagnostic imaging/*drug therapy
MH  - Thrombocytopenia/*chemically induced/complications/*drug therapy
MH  - Ultrasonography
MH  - Young Adult
PMC - PMC3539579
EDAT- 2011/04/29 06:00
MHDA- 2011/08/19 06:00
PMCR- 2011/05/01
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - 881753 [pii]
AID - 10.12659/msm.881753 [doi]
PST - ppublish
SO  - Med Sci Monit. 2011 May;17(5):CS56-9. doi: 10.12659/msm.881753.