PMID- 21525878
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20221207
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 56
IP  - 7
DP  - 2011 Jul
TI  - A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is 
      associated with Buerger disease but not with Takayasu arteritis in Japanese.
PG  - 545-7
LID - 10.1038/jhg.2011.44 [doi]
AB  - Buerger disease (BD) and Takayasu arteritis (TA) are rare vascular disorders. 
      Although their etiology and pathogenesis have not been elucidated, several 
      studies have suggested the involvement of innate immunity. Myeloid 
      differentiation primary-response protein 88 (MyD88) is a key signaling adaptor 
      for all Toll-like receptors, which have a central role in innate immunity. In the 
      present study, we evaluated the association of MyD88 with BD and TA. We conducted 
      case-control studies in Japanese populations composing of 131 BD cases, 90 TA 
      cases and 270 healthy controls to be genotyped for a single nucleotide 
      polymorphism rs7744 A>G in the 3'-untranslated region of MyD88 gene. The 
      frequency of GG genotype was significantly lower in the BD patients than in the 
      controls (6.9 vs 15.9%, P=0.011, odds ratio=0.39, 95% confidence interval; 0.19, 
      0.81), although there was no significant difference in the genotype frequencies 
      between the TA patients and controls. It was suggested that MyD88 may confer 
      resistance to BD in Japanese. Because this is the first report of the association 
      between MyD88 and BD, replication studies in other cohorts are required.
FAU - Chen, Zhiyong
AU  - Chen Z
AD  - Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical 
      and Dental University, Tokyo, Japan.
FAU - Nakajima, Toshiaki
AU  - Nakajima T
FAU - Inoue, Yoshinori
AU  - Inoue Y
FAU - Kudo, Toshifumi
AU  - Kudo T
FAU - Jibiki, Masatoshi
AU  - Jibiki M
FAU - Iwai, Takehisa
AU  - Iwai T
FAU - Kimura, Akinori
AU  - Kimura A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110428
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (3' Untranslated Regions)
RN  - 0 (MYD88 protein, human)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - 3' Untranslated Regions/*genetics
MH  - Asian People
MH  - Case-Control Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Myeloid Differentiation Factor 88/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Takayasu Arteritis/*genetics
MH  - Thromboangiitis Obliterans/*genetics
MH  - Toll-Like Receptors/genetics
EDAT- 2011/04/29 06:00
MHDA- 2012/02/04 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
AID - jhg201144 [pii]
AID - 10.1038/jhg.2011.44 [doi]
PST - ppublish
SO  - J Hum Genet. 2011 Jul;56(7):545-7. doi: 10.1038/jhg.2011.44. Epub 2011 Apr 28.