PMID- 21526982
OWN - NLM
STAT- MEDLINE
DCOM- 20110812
LR  - 20211020
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Print)
IS  - 0143-5221 (Linking)
VI  - 121
IP  - 6
DP  - 2011 Sep
TI  - Clinical and haemodynamic correlates of heart rate turbulence as a non-invasive 
      index of baroreflex sensitivity in chronic heart failure.
PG  - 279-84
LID - 10.1042/CS20110063 [doi]
AB  - HRT (heart rate turbulence), describing the heart rate changes following a 
      premature ventricular contraction, has been regarded as an indirect index of 
      baroreflex function. However, limited data are available on its relationship with 
      invasive assessment by phenylephrine injection (Phe-slope). In the present study, 
      we therefore compared these methodologies in a series of patients with HF (heart 
      failure) in which both measures together with clinical and haemodynamic data were 
      available. HRT parameters [TO (turbulence onset) and TS (turbulence slope)] were 
      measured from 24-h Holter recordings obtained within 1 week of baroreflex 
      sensitivity assessment and right heart haemodynamic evaluation (Swan-Ganz 
      catheter). HRT was computable in 135 out of 157 (86%) patients who had both a 
      phenylephrine test and haemodynamic evaluation. TO and TS significantly 
      correlated with Phe-slope (r=-0.39, P<0.0001 and r=0.66, P<0.0001 respectively). 
      Age, baseline heart rate, LVEF (left ventricular ejection fraction), PCP 
      (pulmonary capillary pressure), CI (cardiac index) and sodium were significant 
      and independent predictors of Phe-slope, accounting for 51% of its variability. 
      Similarly, age, baseline heart rate and PCP, and NYHA (New York Heart 
      Association) classes III-IV were independent predictors for TS and explained 48% 
      of its variability, whereas only CI and LVEF were found to be significantly 
      related to TO and explained a very limited proportion (20%) of the variability. 
      In conclusion, these results suggest that HRT may be regarded as a surrogate 
      measure of baroreflex sensitivity in clinical and prognostic evaluation in 
      patients with HF.
FAU - La Rovere, Maria Teresa
AU  - La Rovere MT
AD  - Department of Cardiology, S. Maugeri Foundation, Scientific Institute of 
      Montescano, IRCCS, Montescano, Pavia, Italy. mariateresa.larovere@fsm.it
FAU - Maestri, Roberto
AU  - Maestri R
FAU - Pinna, Gian Domenico
AU  - Pinna GD
FAU - Sleight, Peter
AU  - Sleight P
FAU - Febo, Oreste
AU  - Febo O
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Cardiotonic Agents)
RN  - 1WS297W6MV (Phenylephrine)
SB  - IM
MH  - Baroreflex/*physiology
MH  - Cardiac Output/physiology
MH  - Cardiotonic Agents
MH  - Electrocardiography, Ambulatory/methods
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenylephrine
MH  - Prognosis
MH  - Pulmonary Wedge Pressure/physiology
MH  - Retrospective Studies
MH  - Stroke Volume/physiology
MH  - Ventricular Premature Complexes/*physiopathology
PMC - PMC3193846
EDAT- 2011/04/30 06:00
MHDA- 2011/08/13 06:00
PMCR- 2011/05/27
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
PHST- 2011/05/27 00:00 [pmc-release]
AID - CS20110063 [pii]
AID - cs1210279 [pii]
AID - 10.1042/CS20110063 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2011 Sep;121(6):279-84. doi: 10.1042/CS20110063.