PMID- 21527903
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20240422
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Print)
IS  - 0743-8346 (Linking)
VI  - 31
IP  - 12
DP  - 2011 Dec
TI  - Country-specific birth weight and length in type 1 diabetes high-risk HLA 
      genotypes in combination with prenatal characteristics.
PG  - 764-9
LID - 10.1038/jp.2011.26 [doi]
AB  - OBJECTIVE: To examine the relationship between high-risk human leukocyte antigen 
      (HLA) genotypes for type 1 diabetes and birth size in combination with prenatal 
      ch aracteristics in different countries. STUDY DESIGN: Four high-risk HLA 
      genotypes were enrolled in the Environmental determinants of Diabetes in the 
      Young study newborn babies from the general population in Finland, Germany, 
      Sweden and the United States. Stepwise regression analyses were used to adjust 
      for country, parental physical characteristics and environmental factors during 
      pregnancy. RESULT: Regression analyses did not reveal differences in birth size 
      between the four type 1 diabetes high-risk HLA genotypes. Compared with DQ 4/8 in 
      each country, (1) DQ 2/2 children were heavier in the United States (P=0.028) 
      mostly explained however, by parental weight; (2) DQ 2/8 (P=0.023) and DQ 8/8 
      (P=0.046) children were longer in Sweden independent of parents height and as 
      well as (3) in the United States for DQ 2/8 (P=0.023), but again dependent on 
      parental height. CONCLUSION: Children born with type 1 diabetes high-risk HLA 
      genotypes have comparable birth size. Longitudinal follow-up of these children 
      should reveal whether birth size differences between countries contribute to the 
      risk for islet autoimmunity and type 1 diabetes.
FAU - Sterner, Y
AU  - Sterner Y
AD  - Department of Clinical Sciences, Lund University/CRC, University Hospital MAS, 
      Malmo, Sweden.
FAU - Torn, C
AU  - Torn C
FAU - Lee, H-S
AU  - Lee HS
FAU - Larsson, H
AU  - Larsson H
FAU - Winkler, C
AU  - Winkler C
FAU - McLeod, W
AU  - McLeod W
FAU - Lynch, K
AU  - Lynch K
FAU - Simell, O
AU  - Simell O
FAU - Ziegler, A
AU  - Ziegler A
FAU - Schatz, D
AU  - Schatz D
FAU - Hagopian, W
AU  - Hagopian W
FAU - Rewers, M
AU  - Rewers M
FAU - She, J-X
AU  - She JX
FAU - Krischer, J P
AU  - Krischer JP
FAU - Akolkar, B
AU  - Akolkar B
FAU - Lernmark, A
AU  - Lernmark A
CN  - TEDDY Study Group
LA  - eng
GR  - DK 63865/DK/NIDDK NIH HHS/United States
GR  - DK 63821/DK/NIDDK NIH HHS/United States
GR  - UC4 DK063821/DK/NIDDK NIH HHS/United States
GR  - HHSN267200700014C/DK/NIDDK NIH HHS/United States
GR  - U01 DK063861/DK/NIDDK NIH HHS/United States
GR  - DK 63790/DK/NIDDK NIH HHS/United States
GR  - UC4 DK063865/DK/NIDDK NIH HHS/United States
GR  - DK 63836/DK/NIDDK NIH HHS/United States
GR  - DK 63861/DK/NIDDK NIH HHS/United States
GR  - DK 63863/DK/NIDDK NIH HHS/United States
GR  - U01 DK063829/DK/NIDDK NIH HHS/United States
GR  - U01 DK063865/DK/NIDDK NIH HHS/United States
GR  - DK 63829/DK/NIDDK NIH HHS/United States
GR  - UC4 DK063861/DK/NIDDK NIH HHS/United States
GR  - UC4 DK063829/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110428
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal 
      Association
JID - 8501884
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - *Birth Weight
MH  - *Body Height
MH  - Body Weight
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Finland
MH  - *Genetic Predisposition to Disease
MH  - *Genotype
MH  - Germany
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Parents
MH  - Pregnancy
MH  - Risk Factors
MH  - Sweden
MH  - United States
PMC - PMC3226663
EDAT- 2011/04/30 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - jp201126 [pii]
AID - 10.1038/jp.2011.26 [doi]
PST - ppublish
SO  - J Perinatol. 2011 Dec;31(12):764-9. doi: 10.1038/jp.2011.26. Epub 2011 Apr 28.