PMID- 2152817
OWN - NLM
STAT- MEDLINE
DCOM- 19900122
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 64
IP  - 1
DP  - 1990 Jan
TI  - Human herpesvirus 6 is closely related to human cytomegalovirus.
PG  - 287-99
AB  - A sequence of 21,858 base pairs from the genome of human herpesvirus 6 (HHV-6) 
      strain U1102 is presented. The sequence has a mean composition of 41% G + C, and 
      the observed frequency of CpG dinucleotides is close to that predicted from this 
      mononucleotide composition. The sequence contains 17 complete open reading frames 
      (ORFs) and part of another at the 5' end of the sequence. The predicted protein 
      products of two of these ORFs have no recognizable homologs in the genomes of 
      other sequenced human herpesviruses (i.e., Epstein-Barr virus [EBV], human 
      cytomegalovirus [HCMV], herpes simplex virus [HSV], and varicella-zoster virus 
      [VZV]). However, the products of nine other ORFs are clearly homologous to a set 
      of genes that is conserved in all other sequenced herpesviruses, including 
      homologs of the alkaline exonuclease, the phosphotransferase, the spliced ORF, 
      and the major capsid protein genes. Measurements of similarity between these 
      homologous sequences showed that HHV-6 is clearly most closely related to HCMV. 
      The degree of relatedness between HHV-6 and HCMV was commensurate with that 
      observed in comparisons between HSV and VZV or EBV and herpesvirus saimiri and 
      significantly greater than its relatedness to EBV, HSV, or VZV. In addition, the 
      gene for the major capsid protein and its 5' neighbor are reoriented with respect 
      to the spliced ORFs in the genomes of both HHV-6 and HCMV relative to the 
      organization observed in EBV, HSV, and VZV. Three ORFs in HHV-6 have recognizable 
      homologs only in the genome of HCMV. Despite differences in gross composition and 
      size, we conclude that the genomes of HHV-6 and HCMV are closely related.
FAU - Lawrence, G L
AU  - Lawrence GL
AD  - Medical Research Council Laboratory of Molecular Biology, Cambridge, United 
      Kingdom.
FAU - Chee, M
AU  - Chee M
FAU - Craxton, M A
AU  - Craxton MA
FAU - Gompels, U A
AU  - Gompels UA
FAU - Honess, R W
AU  - Honess RW
FAU - Barrell, B G
AU  - Barrell BG
LA  - eng
SI  - GENBANK/M28243
SI  - GENBANK/M68963
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Recombinant)
RN  - 0 (DNA, Viral)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Cytomegalovirus/*genetics
MH  - DNA, Recombinant/isolation & purification
MH  - DNA, Viral/genetics
MH  - Exons
MH  - *Genes, Viral
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
MH  - Simplexvirus/*genetics
MH  - Viral Structural Proteins/genetics
PMC - PMC249101
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
PMCR- 1990/01/01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PHST- 1990/01/01 00:00 [pmc-release]
AID - 10.1128/JVI.64.1.287-299.1990 [doi]
PST - ppublish
SO  - J Virol. 1990 Jan;64(1):287-99. doi: 10.1128/JVI.64.1.287-299.1990.