PMID- 21529268
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20151119
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 33
IP  - 4
DP  - 2011
TI  - Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 
      concentrations with cardiovascular disease in patients with chronic kidney 
      disease.
PG  - 398-404
LID - 10.3109/0886022X.2011.568136 [doi]
AB  - Both pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1) are 
      mediators of inflammation. They also appear to play critical roles in vascular 
      endothelial dysfunction but their associations with cardiorenal syndrome remain 
      largely unknown. The objective of this study was to examine their associations 
      with cardiorenal syndrome. Circulating levels of PTX3, MCP-1, and some other 
      biomarkers were evaluated in 134 patients with chronic kidney disease (CKD) 
      and/or cardiovascular disease (CVD) and 55 age- and gender-matched subjects 
      without CKD or CVD. Levels of PTX3, high-sensitivity C-reactive protein (hsCRP), 
      and tumor necrosis factor alpha (TNFalpha) were significantly higher in CKD patients with 
      CVD than in those without CVD. In advanced CKD patients (estimated glomerular 
      filtration rate < 30 mL/min/1.73 m(2)), the values of area under the curve of PTX3, 
      TNFalpha, and hsCRP for the detection of the association of CVD were 0.664, 0.507, 
      and 0.318, respectively. In contrast, serum levels of MCP-1 were significantly 
      higher in CKD patients than in control subjects independently of association with 
      CVD. PTX3, hsCRP, and TNFalpha, but not MCP-1 could predict the presence of CVD as a 
      complication associated with CKD. Additionally, PTX3 might be a more sensitive 
      marker for the association of CVD than hsCRP and TNFalpha in patients with advanced 
      CKD.
FAU - Nishi, Keiko
AU  - Nishi K
AD  - Division of Circulatory and Body Fluid Regulation, Department of Internal 
      Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
FAU - Imamura, Takuroh
AU  - Imamura T
FAU - Kitamura, Kazuo
AU  - Kitamura K
FAU - Ogawa, Tsuneo
AU  - Ogawa T
FAU - Fujimoto, Shouichi
AU  - Fujimoto S
FAU - Kakitsubata, Yousuke
AU  - Kakitsubata Y
FAU - Ishikawa, Tadashi
AU  - Ishikawa T
FAU - Asada, Yujiro
AU  - Asada Y
FAU - Kodama, Tatsuhiko
AU  - Kodama T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Serum Amyloid P-Component)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Cardiovascular Diseases/blood/*etiology
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/blood/*complications
MH  - Serum Amyloid P-Component/*metabolism
EDAT- 2011/05/03 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.3109/0886022X.2011.568136 [doi]
PST - ppublish
SO  - Ren Fail. 2011;33(4):398-404. doi: 10.3109/0886022X.2011.568136.