PMID- 21532532
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20170306
VI  - 121
IP  - 4
DP  - 2011 Apr
TI  - Increase in plasma sCD23 levels precedes immunoglobulin E elevation after 
      coronary artery bypass graft surgery.
PG  - 109-14
LID - 524 [pii]
AB  - INTRODUCTION: Recent reports have confirmed an increase in plasma immunoglobulin 
      E (IgE), which had been previously observed in clinical situations associated 
      with tissue injury. Studies on the regulation of IgE levels have pointed to the 
      role of low-affinity IgE receptor, i.e., sFcepsilonRII (soluble CD23 [sCD23]). 
      OBJECTIVES: The aim of the study was to assess the changes in the levels of this 
      receptor in response to surgical injury during coronary artery bypass grafting. 
      PATIENTS AND METHODS: The study group consisted of 33 patients (28 men and 5 
      women, aged 45-75 years). Blood samples were obtained from all patients before 
      surgery and 24, 48, 72, and 120 hours after the surgery. The expression of FcepsilonRII 
      on B cells was measured using flow cytometry and plasma levels of sCD23 were 
      determined by an enzyme-linked immunosorbent assay. RESULTS: We observed a 
      significant increase in the total number of leukocytes and a significant decrease 
      in the total number of lymphocytes with a simultaneous increase in the proportion 
      of B cells (P <0.001). At the same time, the percentage of CD23-positive B cells 
      (CD19/23+) decreased significantly (P <0.001) at 24 hours after surgery and 
      remained low over the period of 72 hours. The plasma levels of sCD23 increased 
      significantly (P <0.05) at 24 hours after surgery and remained elevated until the 
      end of follow-up. All the above changes in the immune status preceded an increase 
      in plasma IgE levels (P <0.001), which reached peak values on the fifth day after 
      surgery (120 h). CONCLUSIONS: Surgical procedures are associated with a transient 
      increase in plasma IgE levels, which is preceded by an increase in the level of 
      sCD23 and a simultaneous decrease in the expression of CD23 on B cells. FcepsilonRII 
      (CD23) and sFcepsilonRII (sCD23) may be involved in the regulation of IgE levels after 
      trauma.
FAU - Marciniak-Sroka, Joanna
AU  - Marciniak-Sroka J
AD  - 2nd Department of Medicine, Jagiellonian University Medical College, ul. 
      Grzegorzecka 16, Krakow, Poland.
FAU - Jawien, Jacek
AU  - Jawien J
FAU - Jakiela, Bogdan
AU  - Jakiela B
FAU - Szczeklik, Andrzej
AU  - Szczeklik A
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aged
MH  - *Coronary Artery Bypass
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Receptors, IgE/*blood
EDAT- 2011/05/03 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 524 [pii]
PST - ppublish
SO  - Pol Arch Med Wewn. 2011 Apr;121(4):109-14.