PMID- 21532752
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Apr 12
TI  - Chemokine (C-C motif) ligand 2 (CCL2) in sera of patients with type 1 diabetes 
      and diabetic complications.
PG  - e17822
LID - 10.1371/journal.pone.0017822 [doi]
LID - e17822
AB  - BACKGROUND: Chemokine (C-C motif) ligand 2 (CCL2), commonly known as monocyte 
      chemoattractant protein-1 (MCP-1), has been implicated in the pathogenesis of 
      many diseases characterized by monocytic infiltration. However, limited data have 
      been reported on MCP-1 in type 1 diabetes (T1D) and the findings are inconclusive 
      and inconsistent. METHODS: In this study, MCP-1 was measured in the sera from 
      2,472 T1D patients and 2,654 healthy controls using a Luminex assay. The 
      rs1024611 SNP in the promoter region of MCP-1 was genotyped for a subset of 
      subjects (1764 T1D patients and 1323 controls) using the TaqMan-assay. RESULTS: 
      Subject age, sex or genotypes of MCP-1 rs1024611SNP did not have a major impact 
      on serum MCP-1 levels in either healthy controls or patients. While hemoglobin 
      A1c levels did not have a major influence on serum MCP-1 levels, the mean serum 
      MCP-1 levels are significantly higher in patients with multiple complications 
      (mean = 242 ng/ml) compared to patients without any complications (mean = 201 
      ng/ml) (p = 3.5x10(-6)). Furthermore, mean serum MCP-1 is higher in controls 
      (mean = 261 ng/ml) than T1D patients (mean = 208 ng/ml) (p<10(-23)). More 
      importantly, the frequency of subjects with extremely high levels (>99(th) 
      percentile of patients or 955 ng/ml) of serum MCP-1 is significantly lower in the 
      T1D group compared to the control group (odds ratio = 0.11, p<10(-33)). 
      CONCLUSION: MCP-1 may have a dual role in T1D and its complications. While very 
      high levels of serum MCP-1 may be protective against the development of T1D, 
      complications are associated with higher serum MCP-1 levels within the T1D group.
FAU - Guan, Ruili
AU  - Guan R
AD  - Institute of Translational Medicine and School of Pharmaceutical Sciences, 
      Nanjing University of Technology, Nanjing, Jiangsu, People's Republic of China.
FAU - Purohit, Sharad
AU  - Purohit S
FAU - Wang, Hongjie
AU  - Wang H
FAU - Bode, Bruce
AU  - Bode B
FAU - Reed, John Chip
AU  - Reed JC
FAU - Steed, R Dennis
AU  - Steed RD
FAU - Anderson, Stephen W
AU  - Anderson SW
FAU - Steed, Leigh
AU  - Steed L
FAU - Hopkins, Diane
AU  - Hopkins D
FAU - Xia, Chun
AU  - Xia C
FAU - She, Jin-Xiong
AU  - She JX
LA  - eng
GR  - R21 HD050196/HD/NICHD NIH HHS/United States
GR  - R01 HD037800/HD/NICHD NIH HHS/United States
GR  - 4R33-DK069878/DK/NIDDK NIH HHS/United States
GR  - 4R33HD050196/HD/NICHD NIH HHS/United States
GR  - R33 DK069878/DK/NIDDK NIH HHS/United States
GR  - 2R01HD37800/HD/NICHD NIH HHS/United States
GR  - R21 DK069878/DK/NIDDK NIH HHS/United States
GR  - R33 HD050196/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110412
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood/genetics
MH  - Diabetes Mellitus, Type 1/*blood/complications
MH  - Genotype
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
PMC - PMC3075244
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/05/03 06:00
MHDA- 2011/08/31 06:00
PMCR- 2011/04/12
CRDT- 2011/05/03 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/02/12 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
PHST- 2011/04/12 00:00 [pmc-release]
AID - PONE-D-10-05398 [pii]
AID - 10.1371/journal.pone.0017822 [doi]
PST - epublish
SO  - PLoS One. 2011 Apr 12;6(4):e17822. doi: 10.1371/journal.pone.0017822.