PMID- 21532938
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Print)
IS  - 1946-6234 (Linking)
VI  - 2
IP  - 50
DP  - 2010 Sep
TI  - Response to Comment on "The Origins of Sexually Transmitted HIV Among Men Who 
      Have Sex with Men".
PG  - 501r1
AB  - In this investigation, we evaluated explanations for the unusual degree of 
      genetic diversity in HIV populations within the sampled seminal cell and plasma 
      compartments observed in our previous study. These analyses included clonal 
      sequencing of HIV DNA in peripheral blood mononuclear cells, ultradeep sequencing 
      of HIV RNA in blood plasma, human leukocyte antigen (HLA) haplotyping of 
      previously used samples, and a BLAST screen against both a local and public 
      repository of HIV-1 sequences, and the investigations to determine whether these 
      observations were secondary to contamination or artifact were unsuccessful. As 
      there are very few HIV sequences from seminal cell tissues and transmission pairs 
      described in the literature, future studies that evaluate more transmission pairs 
      with sampling from multiple anatomic compartments and at multiple time points 
      will most likely be required to resolve this controversy.
FAU - Smith, Davey
AU  - Smith D
AD  - University of California, San Diego, La Jolla, CA 92093, USA.
FAU - Delport, Wayne
AU  - Delport W
FAU - Butler, David
AU  - Butler D
FAU - Little, Susan
AU  - Little S
FAU - Richman, Douglas
AU  - Richman D
FAU - Pond, Sergei Kosakovsky
AU  - Pond SK
LA  - eng
GR  - R01 AI057167/AI/NIAID NIH HHS/United States
GR  - R21 AI077304/AI/NIAID NIH HHS/United States
GR  - R01 AI047745/AI/NIAID NIH HHS/United States
GR  - UM1 AI069432/AI/NIAID NIH HHS/United States
GR  - U01 AI069432/AI/NIAID NIH HHS/United States
GR  - R56 AI047745/AI/NIAID NIH HHS/United States
GR  - R01 MH083552/MH/NIMH NIH HHS/United States
GR  - R24 AI106039/AI/NIAID NIH HHS/United States
GR  - P30 AI036214-18/AI/NIAID NIH HHS/United States
GR  - R21 AI047745/AI/NIAID NIH HHS/United States
GR  - R01 MH083552-04/MH/NIMH NIH HHS/United States
GR  - U01 AI043638/AI/NIAID NIH HHS/United States
GR  - R01 AI047745-09/AI/NIAID NIH HHS/United States
GR  - P01 AI074621-03S10002/AI/NIAID NIH HHS/United States
GR  - P30 MH062512/MH/NIMH NIH HHS/United States
GR  - R21 AI080353/AI/NIAID NIH HHS/United States
GR  - P30 AI036214/AI/NIAID NIH HHS/United States
GR  - R21 AI077304-02/AI/NIAID NIH HHS/United States
GR  - P01 AI074621/AI/NIAID NIH HHS/United States
GR  - U01 AI043638-09S4/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
PMC - PMC3083242
MID - NIHMS245016
EDAT- 2011/05/03 06:00
MHDA- 2011/05/03 06:01
PMCR- 2011/09/01
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/05/03 06:01 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - 10.1126/scitranslmed.3001473 [doi]
PST - ppublish
SO  - Sci Transl Med. 2010 Sep;2(50):501r1. doi: 10.1126/scitranslmed.3001473.