PMID- 21533283
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Apr 13
TI  - Assessing the influence of different ROI selection strategies on functional 
      connectivity analyses of fMRI data acquired during steady-state conditions.
PG  - e14788
LID - 10.1371/journal.pone.0014788 [doi]
LID - e14788
AB  - In blood oxygen level dependent (BOLD) functional magnetic resonance imaging 
      (fMRI), assessing functional connectivity between and within brain networks from 
      datasets acquired during steady-state conditions has become increasingly common. 
      However, in contrast to connectivity analyses based on task-evoked signal 
      changes, selecting the optimal spatial location of the regions of interest (ROIs) 
      whose timecourses will be extracted and used in subsequent analyses is not 
      straightforward. Moreover, it is also unknown how different choices of the 
      precise anatomical locations within given brain regions influence the estimates 
      of functional connectivity under steady-state conditions. The objective of the 
      present study was to assess the variability in estimates of functional 
      connectivity induced by different anatomical choices of ROI locations for a given 
      brain network. We here targeted the default mode network (DMN) sampled during 
      both resting-state and a continuous verbal 2-back working memory task to compare 
      four different methods to extract ROIs in terms of ROI features (spatial overlap, 
      spatial functional heterogeneity), signal features (signal distribution, mean, 
      variance, correlation) as well as strength of functional connectivity as a 
      function of condition. We show that, while different ROI selection methods 
      produced quantitatively different results, all tested ROI selection methods 
      agreed on the final conclusion that functional connectivity within the DMN 
      decreased during the continuous working memory task compared to rest.
FAU - Marrelec, Guillaume
AU  - Marrelec G
AD  - U678, Inserm, Paris, France. marrelec@imed.jussieu.fr
FAU - Fransson, Peter
AU  - Fransson P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110413
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Probability
PMC - PMC3076321
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2011/05/03 06:00
MHDA- 2011/08/31 06:00
PMCR- 2011/04/13
CRDT- 2011/05/03 06:00
PHST- 2010/03/15 00:00 [received]
PHST- 2011/01/10 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
PHST- 2011/04/13 00:00 [pmc-release]
AID - 10-PONE-RA-17142R2 [pii]
AID - 10.1371/journal.pone.0014788 [doi]
PST - epublish
SO  - PLoS One. 2011 Apr 13;6(4):e14788. doi: 10.1371/journal.pone.0014788.