PMID- 21533403
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110502
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 10
IP  - 3
DP  - 1997 Mar
TI  - Analysis of sex chromosomal numerical aberrations in human astrocytomas by FISH.
PG  - 497-502
AB  - Although sex chromosomal aberrations in astrocytomas have been frequently 
      reported by cytogeneticists, their biologic significance is still unclear. The 
      aim of this study was to investigate sex chromosomal aberrations of astrocytomas 
      by fluorescence in situ hybridization (FISH) and to determine whether there is a 
      relationship between these aberrations and abnormalities of chromosomes 7 and 10. 
      The astrocytoma specimens were obtained from 14 male and 11 female patients. The 
      centromeric probes DYZ1, DXZ1, D7Z1 and D10Z1 were used to determine the 
      numerical changes in chromosomes Y, X, 7, and 10 by FISH. The hybridization spots 
      were counted by fluorescence microscopy. Three cases showed chromosome X 
      aberrations, including two cases with loss of chromosome X and one case with a 
      complex chromosome X aberration among 11 female astrocytomas. Eight cases with 
      loss of chromosome Y were seen among 14 male astrocytomas; one was grade II, 
      three grade III, and four grade IV tumors. One case of disomy X was observed 
      among male grade II tumors. Seven of the eight tumors with loss of chromosome Y 
      had additional complex chromosome aberrations. Our results suggest that sex 
      chromosome aberrations in malignant astrocytomas are non-random and frequent. 
      These changes suggest an association with aberrations of chromosomes 7 and 10. 
      These sex chromosome aberrations seem to be a part of a complex chromosome 
      pattern of aberrations in astrocytomas. The observed abnormalities may not 
      necessarily be a part of the neoplastic progression in malignant astrocytomas, 
      but they may be of biologic significance.
FAU - Liu, X
AU  - Liu X
AD  - KANSAI MED UNIV,DEPT NEUROSURG,MORIGUCHI,OSAKA 570,JAPAN.
FAU - Numa, Y
AU  - Numa Y
FAU - Kasai, H
AU  - Kasai H
FAU - Tsuchida, T
AU  - Tsuchida T
FAU - Kawamoto, K
AU  - Kawamoto K
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PST - ppublish
SO  - Int J Oncol. 1997 Mar;10(3):497-502.