PMID- 21534883
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20201209
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Linking)
VI  - 8
IP  - 2
DP  - 2011 Jun
TI  - Prior exposure to immunosuppressive organophosphorus or organochlorine compounds 
      aggravates the T(H)1- and T(H)2-type allergy caused by topical sensitization to 
      2,4-dinitrochlorobenzene and trimellitic anhydride.
PG  - 170-82
LID - 10.3109/1547691X.2011.566231 [doi]
AB  - Immunosuppressive environmental chemicals may increase the potency of allergens 
      and thereby play a role in the development of allergic diseases. This study's 
      primary objective was to examine the mechanisms behind the relationship between 
      allergic diseases and the immunosuppression induced by some environmental 
      chemicals. We focused on the modulation of allergic potential in vitro and in 
      mice by the organophosphorus pesticide O,O-diethyl-O-4-nitrophenyl-thiophosphate 
      (parathion) and the organochlorine pesticide 
      1,1,1-trichloro-2,2-bis(4-methoxy-phenyl)ethane (methoxychlor), with respect to 
      the T(H)1-type allergen 2,4-dinitrochlorobenzene (DNCB) and the T(H)2-type 
      allergen trimellitic anhydride (TMA). Mice (4-week-old) were orally administered 
      parathion or methoxychlor. Four weeks after the final dosing, the mice were 
      sensitized to DNCB or TMA, and T-lymphocyte proliferation measured in their 
      (using a local lymph node assay [LLNA]). In addition, we analyzed T-lymphocytes 
      via surface antigen expression and local cytokine production in auricular lymph 
      nodes after treatment with 0.1% DNCB or 0.3% TMA. The estimated concentration of 
      DNCB and TMA to yield a stimulation index (SI) of cell proliferation of three 
      decreased markedly in parathion- and methoxychlor-pre-treated mice. Pesticide 
      pre-treatment induced marked increases in the number of helper and cytotoxic 
      T-cells, levels of T(H)1 and T(H)2 cytokines, and gene expression in lymph node 
      cells. According to our results, T(H)1- and T(H)2-type allergies are aggravated 
      by prior exposure to immunosuppressive environmental chemicals.
FAU - Fukuyama, Tomoki
AU  - Fukuyama T
AD  - Institute of Environmental Toxicology, Ibaraki, Japan. fukuyama@iet.or.jp
FAU - Tajima, Yukari
AU  - Tajima Y
FAU - Ueda, Hideo
AU  - Ueda H
FAU - Hayashi, Koichi
AU  - Hayashi K
FAU - Kosaka, Tadashi
AU  - Kosaka T
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Insecticides)
RN  - 0 (Irritants)
RN  - 0 (Phthalic Anhydrides)
RN  - 61G466064D (Parathion)
RN  - 80T61EUU7H (trimellitic anhydride)
RN  - RIA79UD69L (Methoxychlor)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/drug effects
MH  - Dinitrochlorobenzene/*adverse effects/pharmacology
MH  - Drug Hypersensitivity/*immunology/pathology
MH  - Female
MH  - Humans
MH  - Insecticides/*adverse effects/pharmacology
MH  - Irritants/*adverse effects/pharmacology
MH  - Jurkat Cells
MH  - Methoxychlor/*adverse effects/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Parathion/*adverse effects/pharmacology
MH  - Phthalic Anhydrides/*adverse effects/pharmacology
MH  - Th1 Cells/*immunology/pathology
MH  - Th2 Cells/*immunology/pathology
EDAT- 2011/05/04 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - 10.3109/1547691X.2011.566231 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2011 Jun;8(2):170-82. doi: 10.3109/1547691X.2011.566231.