PMID- 21535319
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20220330
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 23
IP  - 8
DP  - 2011 Aug
TI  - Increasing body weight enhances prevalence and proximal extent of reflux in GERD 
      patients 'on' and 'off' PPI therapy.
PG  - 724-e327
LID - 10.1111/j.1365-2982.2011.01720.x [doi]
AB  - BACKGROUND: Increased body weight is associated with higher intragastric 
      pressure. Proximal extent of reflux is a determinant of symptoms in patients with 
      gastro-esophageal reflux disease (GERD). We aimed to investigate the association 
      between body mass index (BMI) and abdominal circumference on the incidence and 
      proximal extent of reflux. METHODS: A total of 95 patients [37 men, age 51(16-82) 
      years] with typical and/or atypical GERD symptoms underwent 24 h impedance-pH 
      monitoring. Forty-nine patients were studied 'off' and 46 'on' proton pump 
      inhibitors (PPI) treatment. Reflux was classified as acid (pH < 4) or weakly 
      acidic (pH 4-7). Proximal extent was defined as the number of reflux events 
      reaching >/=15 cm above the lower esophageal sphincter. Body mass index and 
      abdominal circumference (cm) were assessed. KEY RESULTS: In patients 'off' PPI, 
      there was a correlation between BMI and esophageal acid exposure (rho = 0.53, 
      P < 0.001), volume exposure (rho = 0.48, P < 0.001), total number of reflux events 
      (rho = 0.47, P < 0.001) and number of acid reflux events (rho = 0.49, P < 0.001). In 
      patients 'on' PPI there was a correlation between BMI and esophageal acid 
      exposure (rho = 0.32, P = 0.03), volume exposure (rho = 0.46, P < 0.01) and total 
      number of reflux events (rho = 0.33, P = 0.03). Similar correlations were found 
      between abdominal circumference and reflux. A correlation between BMI and 
      proximal extent of reflux was present in patients 'off' PPI (rho = 0.32, P = 0.03). 
      In patients 'on' PPI, we found a correlation between abdominal circumference and 
      proximal extent (rho = 0.31, P = 0.03). CONCLUSIONS & INFERENCES: Body mass index 
      and abdominal circumference may contribute to GER and its proximal extent, in 
      patients 'on and 'off' PPI. Further studies investigating the role of weight 
      reduction in the control of GERD symptoms are warranted.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Blondeau, K
AU  - Blondeau K
AD  - Translational Research Center for Gastrointestinal Disorders, K.U. Leuven, 49 
      Herestraat, Leuven, Belgium. jan.tack@med.kuleuven.be
FAU - Boecxstaens, V
AU  - Boecxstaens V
FAU - Van Oudenhove, L
AU  - Van Oudenhove L
FAU - Farre, R
AU  - Farre R
FAU - Boeckxstaens, G
AU  - Boeckxstaens G
FAU - Tack, J
AU  - Tack J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110428
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - *Body Weight
MH  - Electric Impedance
MH  - Esophageal pH Monitoring
MH  - Gastroesophageal Reflux/*drug therapy/epidemiology/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - *Weight Gain
MH  - Young Adult
EDAT- 2011/05/04 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1111/j.1365-2982.2011.01720.x [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2011 Aug;23(8):724-e327. doi: 
      10.1111/j.1365-2982.2011.01720.x. Epub 2011 Apr 28.