PMID- 21535955
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20110503
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Mar
TI  - [Clinical and laboratory characteristics of hematological diseases associated 
      with eosinophilia].
PG  - 173-7
AB  - OBJECTIVE: To analyze the clinical and laboratory characteristics of 
      hematological diseases associated with eosinophilia. METHODS: Karyotype analysis 
      was performed by direct method and/or short-time culture of bone marrow cells for 
      R-banding. Fluorescence in situ hybridization (FISH) was performed using PDGFRalpha, 
      PDGFRbeta and FGFR1 break-apart probes. RESULTS: The clinical and hematological 
      findings of 44 patients were diagnosed as hematological diseases associated with 
      eosinophilia. Abnormal karyotypes were detected in 6 cases (13.64%) with 
      karyotyping. The efficiency of the detection of abnormal clone was markedly 
      increased to 29.55% (13/44) with FISH techniques, including 7 cases with 
      FIP1L1-PDGFRalpha (F/P, 15.91%), 3(6.82%) PDGFRalpha rearrangement, 2 (4.55%) aberrant 
      PDGFRbeta gene and 1(2.27%) FGFR1 rearrangement. Patients being PDGFRalpha, PDGFRbeta or 
      FGFR1 positive (13 cases) or negative (31 cases) showed predominant difference in 
      clinical and laboratory features. The incidence of gut involvement, the absolute 
      count of eosinophils in peripheral blood and the percentage of immature 
      eosinophils in bone marrow were significantly increased in positive patients (P < 
      0.05). CONCLUSIONS: The hematological diseases associated with eosinophilia are 
      characterized by unique clinical and laboratory features. Karyotyping should be a 
      routine approach to detect the abnormal clone in these diseases. Screening for 
      PDGFRalpha, PDGFRbeta and FGFR1 gene with FISH can provide more genetic information.
FAU - Gong, Sheng-lan
AU  - Gong SL
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, China.
FAU - Qiu, Hui-ying
AU  - Qiu HY
FAU - Hu, Xiao-xia
AU  - Hu XX
FAU - Song, Xian-min
AU  - Song XM
FAU - Yang, Jian-min
AU  - Yang JM
FAU - Wang, Jian-min
AU  - Wang JM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha)
SB  - IM
MH  - Abnormal Karyotype
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Cytogenetics
MH  - Eosinophilia/etiology/*genetics
MH  - Female
MH  - Hematologic Diseases/complications/*genetics
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Receptor, Platelet-Derived Growth Factor alpha/genetics
MH  - Young Adult
EDAT- 2011/05/04 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2011 Mar;32(3):173-7.