PMID- 2153898
OWN - NLM
STAT- MEDLINE
DCOM- 19900301
LR  - 20190824
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 7
IP  - 1
DP  - 1990 Jan
TI  - Day-night variation in prepro vasoactive intestinal peptide/peptide histidine 
      isoleucine mRNA within the rat suprachiasmatic nucleus.
PG  - 85-9
AB  - Neurons within the suprachiasmatic nuclei of the hypothalamus (SCN) appear to 
      function as a circadian clock that controls the timing of many physiological 
      systems. The SCN contain several chemically distinct neuronal subpopulations, 
      including a large group of interneurons within the ventrolateral SCN that exhibit 
      co-localizable immunoreactivity for both vasoactive intestinal peptide (VIP) and 
      peptide histidine isoleucine (PHI). The purpose of the present study was to 
      determine whether VIP/PHI neurons within the rat SCN exhibit rhythmicity in the 
      cellular levels of the messenger RNA encoding the precursor from which both VIP 
      and PHI are derived. Using both quantitative in situ and solution hybridization 
      prepro-VIP/PHI mRNA levels early in the dark phase were demonstrated to be 
      significantly higher than those 5 h after the onset of the daily light period. 
      Since no statistically reliable (P greater than 0.05) day-night variation was 
      observed in the levels of prepro-VIP/PHI mRNA within cortex, these data suggest 
      that the rhythmicity in prepro-VIP/PHI mRNA is an intrinsic property of 
      VIP/PHI-containing SCN neurons, or rhythmically driven by local synaptic events 
      within the SCN.
FAU - Albers, H E
AU  - Albers HE
AD  - Department of Biology, Georgia State University, Atlanta 30303.
FAU - Stopa, E G
AU  - Stopa EG
FAU - Zoeller, R T
AU  - Zoeller RT
FAU - Kauer, J S
AU  - Kauer JS
FAU - King, J C
AU  - King JC
FAU - Fink, J S
AU  - Fink JS
FAU - Mobtaker, H
AU  - Mobtaker H
FAU - Wolfe, H
AU  - Wolfe H
LA  - eng
GR  - 1K 11AG00295-02/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Peptide PHI)
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 81032-41-9 (preprovasoactive intestinal peptide)
SB  - IM
MH  - Animals
MH  - *Circadian Rhythm
MH  - Male
MH  - Nucleic Acid Hybridization
MH  - Peptide PHI/*metabolism/physiology
MH  - Protein Precursors/*metabolism/physiology
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Suprachiasmatic Nucleus/*metabolism/physiology
MH  - Vasoactive Intestinal Peptide/*metabolism/physiology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 0169-328X(90)90077-Q [pii]
AID - 10.1016/0169-328x(90)90077-q [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1990 Jan;7(1):85-9. doi: 10.1016/0169-328x(90)90077-q.