PMID- 21539708
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20120103
IS  - 1610-0387 (Electronic)
IS  - 1610-0379 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Jan
TI  - Animal-type melanoma - tumor cell invasion of dermal lymphatics and molecular 
      identification of lymph node metastasis.
PG  - 38-41
LID - 10.1111/j.1610-0387.2011.07688.x [doi]
AB  - Animal-type melanoma (ATM) represents a rare subtype within the wide spectrum of 
      melanocytic tumors. Clinically, ATM lesions appear as sharply demarcated, brown, 
      black and dark blue pigmented nodules, which show grey-white surface elements on 
      dermatoscopy. The tumor is restricted to the dermis and arranged in irregular 
      fascicles, which are composed of spindle-shaped and epithelioid melanocytes. 
      Moderate tumor cell pleomorphism, mitoses and apoptotic cells all suggest a 
      malignant process. Abundant, finely dispersed melanin pigment within tumor cells 
      as well as numerous melanophages are strongly suggestive of ATM. Even though 
      locoregional lymph node metastases are frequently found at diagnosis, the course 
      of ATM is generally benign. Specific molecular changes may be detected in 
      melanocytes from lesions and lymph nodes on fluorescence in situ hybridization 
      (FISH). Such findings strongly indicate the malignant potential of ATM. The 
      peculiar biology of ATM, as a moderately malignant tumor, is reflected in a new 
      histopathological classification within the spectrum of dermal borderline 
      melanocytic tumors (BMT).
CI  - (c) The Authors * Journal compilation (c) Blackwell Verlag GmbH, Berlin.
FAU - Posch, Christian
AU  - Posch C
AD  - Department of Dermatology, Rudolfstiftung Hospital, Vienna, Austria. 
      christian.posch@wienkav.at
FAU - Vesely, Michael
AU  - Vesely M
FAU - Monshi, Babak
AU  - Monshi B
FAU - Feichtinger, Hans
AU  - Feichtinger H
FAU - Cziegler, Kurt
AU  - Cziegler K
FAU - Rappersberger, Klemens
AU  - Rappersberger K
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110503
PL  - Germany
TA  - J Dtsch Dermatol Ges
JT  - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German 
      Society of Dermatology : JDDG
JID - 101164708
SB  - IM
MH  - Humans
MH  - Lymph Nodes/*metabolism/*pathology
MH  - Lymphatic Metastasis
MH  - Melanoma/classification/*pathology/*secondary
MH  - Neoplasm Invasiveness
MH  - Skin Neoplasms/classification/*pathology/*secondary
EDAT- 2011/05/05 06:00
MHDA- 2013/06/01 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 10.1111/j.1610-0387.2011.07688.x [doi]
PST - ppublish
SO  - J Dtsch Dermatol Ges. 2012 Jan;10(1):38-41. doi: 
      10.1111/j.1610-0387.2011.07688.x. Epub 2011 May 3.