PMID- 21539884
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20110711
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 60
IP  - 3
DP  - 2011 Aug
TI  - The regulatory use of the Local Lymph Node Assay for the notification of new 
      chemicals in Europe.
PG  - 300-7
LID - 10.1016/j.yrtph.2011.04.006 [doi]
AB  - The regulatory use of the Local Lymph Node Assay (LLNA) for new chemicals 
      registration was monitored by screening the New Chemicals Database (NCD), which 
      was managed by the former European Chemicals Bureau (ECB) at the European 
      Commission Joint Research Centre (JRC). The NCD centralised information for 
      chemicals notified after 1981, where toxicological information has been generated 
      predominantly according to approved test methods. The database was searched to 
      extract notifications for which the information for skin sensitisation labelling 
      was based on results derived with the LLNA. The details of these records were 
      extracted and pooled, and evaluated with regard to the extent of use of the LLNA 
      over time, as well as for analysing the information retrieved on critical aspects 
      of the procedure e.g. strain and amount of animals used, lymph node processing, 
      solvent and doses selected, stimulation indices, and for assessing their level of 
      compliance to the OECD Test Guideline 429. In addition the accuracy of the 
      reduced LLNA when applied to new chemicals was investigated.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Angers-Loustau, Alexandre
AU  - Angers-Loustau A
AD  - In Vitro Methods Unit/ECVAM, Institute for Health and Consumer Protection, 
      European Commission Joint Research Centre, Ispra, Italy.
FAU - Tosti, Luca
AU  - Tosti L
FAU - Casati, Silvia
AU  - Casati S
LA  - eng
PT  - Journal Article
DEP - 20110424
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Irritants)
SB  - IM
MH  - Animals
MH  - Data Mining
MH  - Databases, Factual
MH  - Dermatitis, Allergic Contact/etiology/immunology/pathology
MH  - Dose-Response Relationship, Drug
MH  - Drug Approval/*methods
MH  - Drug Evaluation, Preclinical/*methods
MH  - European Union
MH  - Female
MH  - Immunization/methods
MH  - Irritants/analysis/immunology
MH  - *Local Lymph Node Assay
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Skin/*drug effects/immunology/pathology
EDAT- 2011/05/05 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/05/05 06:00
PHST- 2010/11/04 00:00 [received]
PHST- 2011/04/13 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - S0273-2300(11)00074-2 [pii]
AID - 10.1016/j.yrtph.2011.04.006 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2011 Aug;60(3):300-7. doi: 10.1016/j.yrtph.2011.04.006. 
      Epub 2011 Apr 24.