PMID- 21541483
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20190606
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 9
IP  - 1
DP  - 1996 Jul
TI  - The role of human leukocyte antigen and tumor necrosis factor D as a prognostic, 
      preventive and therapeutic factor in gastric cancer.
PG  - 73-8
AB  - In order to clarify the immunogenetical background, host factors in oncology, 
      human leukocyte antigen (HLA) and tumor necrosis factor (TNF) beta alleles as 
      prognostic, preventive and therapeutic indicators were investigated in 712 
      patients with a histologic diagnosis of adenocarcinoma of the stomach treated 
      with gastrectomy. HLA and TNF beta alleles were tested serologically and by 
      DNA-PCR typing. The absence of HLA Cw1 antigen may represent resistant and 
      prognostic factors. HLA-B51, B61 and TNF beta 10.5 kb homozygote alleles are 
      therapeutic, survival and prognostic factors. Considering the relation with lymph 
      node metastasis, HLA-DR4 antigen and HLA-DRB 1*0405 allele were found to be risk 
      factors for lymph node metastasis in poorly differentiated adenocarcinoma. TNF 
      beta 10.5 kb homozygote allele also represented a risk factor for lymph node 
      metastasis. TNF beta 5.5 kb homozygote allele was considered a resistant factor 
      for lymph node metastasis in poorly differentiated adenocarcinoma. HLA and TNF 
      beta alleles can play an important role as prognostic, preventive and therapeutic 
      indicators in gastric cancer. Therefore, TNMH (TNM with host factor) should be 
      proposed as a new approach.
FAU - Tsuji, K
AU  - Tsuji K
AD  - TOKAI UNIV,SCH MED,DEPT SURG,ISEHARA,KANAGAWA 25911,JAPAN. TOKYO MED COLL,DEPT 
      SURG,SHINJUKU KU,TOKYO 160,JAPAN. CHIBA UNIV,SCH MED,DEPT SURG,CHIBA 280,JAPAN. 
      GUNMA UNIV,SCH MED,DEPT SURG,MAEBASHI,GUMMA 371,JAPAN. KITASATO UNIV,SCH MED,DEPT 
      IMMUNOL,SAGAMIHARA,KANAGAWA 228,JAPAN.
FAU - Ogoshi, K
AU  - Ogoshi K
FAU - Shimura, T
AU  - Shimura T
FAU - Hagihara, M
AU  - Hagihara M
FAU - Isono, K
AU  - Isono K
FAU - Kimura, K
AU  - Kimura K
FAU - Nagamachi, Y
AU  - Nagamachi Y
FAU - Kashiwagi, N
AU  - Kashiwagi N
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
AID - 10.3892/ijo.9.1.73 [doi]
PST - ppublish
SO  - Int J Oncol. 1996 Jul;9(1):73-8. doi: 10.3892/ijo.9.1.73.