PMID- 2154239
OWN - NLM
STAT- MEDLINE
DCOM- 19900320
LR  - 20190510
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 3
IP  - 1
DP  - 1990 Jan
TI  - Clonidine abolishes exaggerated pressor responses to shaker stress in 
      spontaneously hypertensive rats.
PG  - 39-44
AB  - To determine whether clonidine would attenuate exaggerated pressor responses to 
      stress in spontaneously hypertensive rats (SHR), pressor responses to shaker 
      stress were recorded following intracerebroventricular (icv) injections of 
      clonidine in conscious SHR. Pressor responses to shaker stress were significantly 
      larger in SHR than in Wistar-Kyoto rats (WKY). Increased sympathetic nerve 
      responses to shaker stress were also significantly greater in SHR than in WKY. 
      Exaggerated pressor responses in SHR were partly attenuated by adrenalectomy and 
      abolished by clonidine (icv). By contrast, 1-Sar,8-Ile angiotensin II (icv) was 
      ineffective. These findings suggest that in SHR, the alpha-adrenergic system in 
      the brain may contribute to exaggerated pressor responses to shaker stress, but 
      not the brain renin-angiotensin system.
FAU - Takeda, K
AU  - Takeda K
AD  - Second Department of Internal Medicine, Kyoto Prefectural University of Medicine, 
      Japan.
FAU - Okajima, H
AU  - Okajima H
FAU - Nakata, T
AU  - Nakata T
FAU - Kawasaki, S
AU  - Kawasaki S
FAU - Hayashi, J
AU  - Hayashi J
FAU - Oguro, M
AU  - Oguro M
FAU - Sasaki, S
AU  - Sasaki S
FAU - Nakagawa, M
AU  - Nakagawa M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 9088-01-1 (1-Sarcosine-8-Isoleucine Angiotensin II)
RN  - MN3L5RMN02 (Clonidine)
SB  - IM
MH  - 1-Sarcosine-8-Isoleucine Angiotensin II/administration & dosage/pharmacology
MH  - Adrenalectomy
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Central Nervous System/drug effects/physiopathology
MH  - Clonidine/*pharmacology
MH  - Hypertension/drug therapy/physiopathology
MH  - Injections, Intraventricular
MH  - Pressoreceptors/*drug effects/physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Receptors, Adrenergic, alpha/*drug effects/physiology
MH  - Renin-Angiotensin System/drug effects/physiology
MH  - Stress, Physiological/drug therapy/physiopathology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1093/ajh/3.1.39 [doi]
PST - ppublish
SO  - Am J Hypertens. 1990 Jan;3(1):39-44. doi: 10.1093/ajh/3.1.39.