PMID- 21542704
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110930
LR  - 20220330
IS  - 1745-2422 (Electronic)
IS  - 1743-4440 (Linking)
VI  - 8
IP  - 3
DP  - 2011 May
TI  - Cardiac resynchronization therapy for mild-to-moderate heart failure.
PG  - 313-7
LID - 10.1586/erd.11.6 [doi]
AB  - Cardiac resynchronization therapy (CRT) is recognized as a class I indication 
      according to American and European practice guidelines since 2005 in selected 
      patients with systolic heart failure and New York Heart Association (NYHA) III/IV 
      symptoms. There is growing evidence that CRT may also benefit patients who are 
      less symptomatic, as it may delay or even reverse the disease process. In the 
      Resynchronization-Defibrillation for Ambulatory Heart Failure Trial (RAFT), Tang 
      et al. randomized 1798 patients with left ventricular ejection fraction of </= 30%, 
      QRS duration of >/= 120 ms (or paced QRS >/= 200 ms), and NYHA class II or III heart 
      failure to receive an implantable cardioverter-defibrillator (ICD) or an ICD-CRT. 
      After a mean follow-up of 40 months, there was a 25% relative reduction both in 
      the primary outcome of death or heart failure hospitalization (p < 0.001), as 
      well as in the secondary outcome of total mortality (p = 0.003). This landmark 
      trial adds evidence to the efficacy of CRT in selected patients with 
      mild-to-moderate heart failure, at the time of implementation of new guidelines.
FAU - Burri, Haran
AU  - Burri H
AD  - Electrophysiology Unit, Cardiology Service, University Hospital of Geneva, 23 Rue 
      Gabrielle-Gentil, 1211 Geneva, Switzerland. haran.burri@hcuge.ch
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Expert Rev Med Devices
JT  - Expert review of medical devices
JID - 101230445
CON - N Engl J Med. 2010 Dec 16;363(25):2385-95. PMID: 21073365
EDAT- 2011/05/06 06:00
MHDA- 2011/05/06 06:01
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2011/05/06 06:01 [medline]
AID - 10.1586/erd.11.6 [doi]
PST - ppublish
SO  - Expert Rev Med Devices. 2011 May;8(3):313-7. doi: 10.1586/erd.11.6.