PMID- 21543471
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 85
IP  - 14
DP  - 2011 Jul
TI  - Heliothis zea nudivirus 1 gene hhi1 induces apoptosis which is blocked by the 
      Hz-iap2 gene and a noncoding gene, pag1.
PG  - 6856-66
LID - 10.1128/JVI.01843-10 [doi]
AB  - Heliothis zea nudivirus 1 (HzNV-1 or Hz-1 virus), previously regarded as a 
      nonoccluded baculovirus, recently has been placed in the Nudivirus genus. This 
      virus generates HzNV-1 HindIII-I 1 (hhi1) and many other transcripts during 
      productive viral infection; during latent viral infection, however, 
      persistency-associated gene 1 (pag1) is the only gene expressed. In this report, 
      we used transient expression assays to show that hhi1 can trigger strong 
      apoptosis in transfected cells, which can be blocked, at least partially, by the 
      inhibitor of apoptosis genes Autographa californica iap2 (Ac-iap2) and H. zea 
      iap2 (Hz-iap2). In addition to these two genes, unexpectedly, pag1, which encodes 
      a noncoding RNA with no detectable protein product, was found to efficiently 
      suppress hhi1-induced apoptosis. The assay of pro-Sf-caspase-1 processing by hhi1 
      transfection did not detect the small P12 subunit at any of the time intervals 
      tested, suggesting that hhi1 of HzNV-1 induces apoptosis through alternative 
      caspase pathways.
FAU - Wu, Yueh-Lung
AU  - Wu YL
AD  - Institute of Molecular Biology, Academia Sinica, No. 12, Section 2, Academia 
      Road, Taipei 115, Taiwan.
FAU - Wu, Carol P
AU  - Wu CP
FAU - Liu, Catherine Y Y
AU  - Liu CY
FAU - Lee, Song-Tay
AU  - Lee ST
FAU - Lee, Hsiao-Ping
AU  - Lee HP
FAU - Chao, Yu-Chan
AU  - Chao YC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110504
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA Primers)
RN  - 0 (Inhibitor of Apoptosis Proteins)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Base Sequence
MH  - Cell Line
MH  - DNA Primers
MH  - *Genes, Viral
MH  - In Situ Nick-End Labeling
MH  - Inhibitor of Apoptosis Proteins/*genetics
MH  - Nucleopolyhedroviruses/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Spodoptera
PMC - PMC3126586
EDAT- 2011/05/06 06:00
MHDA- 2011/09/16 06:00
PMCR- 2012/01/01
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - JVI.01843-10 [pii]
AID - 1843-10 [pii]
AID - 10.1128/JVI.01843-10 [doi]
PST - ppublish
SO  - J Virol. 2011 Jul;85(14):6856-66. doi: 10.1128/JVI.01843-10. Epub 2011 May 4.