PMID- 21544387
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190606
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 8
IP  - 3
DP  - 1996 Mar
TI  - Increased monocyte chemoattractant protein-1 expression by tumor necrosis 
      factor-alpha can mediate macrophage infiltration in gliomas.
PG  - 493-7
AB  - We compared the in vitro effects of various cytokines on the expression of 
      monocyte chemoattractant protein-1 (MCP-1) in glioma cell lines and found that 
      MCP-1 expression was highly induced by tumor necrosis factor-alpha (TNF alpha) 
      and interleukin-1 beta. The intra-tumoral injection of TNF alpha in rat glioma 
      model increased the in vivo expression of MCP-1 at 1 to 12 h after the injection 
      and induced macrophage infiltration into tumor tissue. The injection of TNF alpha 
      into post-operative tumor cavity of human malignant glioma also increased the 
      concentration of MCP-1 in the cavity fluid at 24 to 38 h after injection. These 
      data, together with the previous finding that the growth of transplanted 
      MCP-1-transfected cells was significantly inhibited by infiltrated macrophages, 
      suggest that injection of TNF alpha inhibits turner growth via the induction of 
      MCP-1 expression.
FAU - Yoshizato, K
AU  - Yoshizato K
AD  - NCI,FREDERICK CANC RES & DEV CTR,IMMUNOBIOL LAB,IMMUNOPATHOL SECT,FREDERICK,MD 
      21701.
FAU - Kuratsu, J
AU  - Kuratsu J
FAU - Takeshima, H
AU  - Takeshima H
FAU - Nishi, T
AU  - Nishi T
FAU - Yoshimura, T
AU  - Yoshimura T
FAU - Ushio, Y
AU  - Ushio Y
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
AID - 10.3892/ijo.8.3.493 [doi]
PST - ppublish
SO  - Int J Oncol. 1996 Mar;8(3):493-7. doi: 10.3892/ijo.8.3.493.