PMID- 21545294
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20190918
IS  - 1938-5404 (Electronic)
IS  - 0033-7587 (Linking)
VI  - 176
IP  - 2
DP  - 2011 Aug
TI  - Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid 
      against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.
PG  - 177-86
AB  - Glycyrrhizic acid has been shown to possess anti-inflammation, antiviral and 
      chemoprotective activity against tumors. We evaluated the protective effects of 
      glycyrrhizic acid in UVB-radiation-induced skin tumor formation in SKH-1 hairless 
      mice and the early molecular biomarkers of these effects. Mice irradiated at 180 
      mJ/cm(2) twice per week showed 100% tumor incidence in 20 weeks. Feeding with 
      glycyrrhizic acid prior to UVB irradiation caused delays in tumor appearance, 
      multiplicity and size. Feeding with glycyrrhizic acid for 2 weeks before a single 
      UVB irradiation (180 mJ/cm(2)) resulted in significant decrease in 
      UVB-radiation-induced thymine dimer-positive cells, expression of proliferative 
      cell nuclear antigen (PCNA), terminal deoxynucleotidyl transferase-mediated dUTP 
      nick end labeling (TUNEL)-positive cells, and apoptotic sunburn cells together 
      with an increase in p53- and p21/Cip1-positive cell populations in epidermis. 
      Simultaneously, glycyrrhizic acid also significantly inhibited NF-kappaB, 
      cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and nitric oxide (NO) levels. 
      Thus glycyrrhizic acid ameliorates UVB-radiation-induced tumorigenesis via 
      downregulation of cell proliferation controls involving thymine dimer, PCNA, 
      apoptosis and transcription factor NF-kappaB and of inflammatory responses involving 
      COX-2, PGE2 and NO while upregulating of p53 and p21/Cip1 to prevent DNA damage 
      and facilitate DNA repair.
FAU - Cherng, Jaw-Ming
AU  - Cherng JM
AD  - Department of Internal Medicine, Chung Shan Medical University Hospital and Chung 
      Shan Medical University, 110 Jianguo N. Road, Sec. 1, Taichung, Taiwan.
FAU - Tsai, Kuen-Daw
AU  - Tsai KD
FAU - Yu, Yu-Whay
AU  - Yu YW
FAU - Lin, Jung-Chung
AU  - Lin JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110505
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
RN  - 0 (Cdkn1a protein, mouse)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (NF-kappa B)
RN  - 0 (Radiation-Protective Agents)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects/radiation effects
MH  - Cell Proliferation/drug effects/radiation effects
MH  - Cyclin-Dependent Kinase Inhibitor p21/metabolism
MH  - Cyclooxygenase 2/metabolism
MH  - DNA Damage
MH  - Epidermis/*drug effects/metabolism/pathology/*radiation effects
MH  - Female
MH  - Glycyrrhizic Acid/*pharmacology
MH  - Mice
MH  - Mice, Hairless
MH  - NF-kappa B/metabolism
MH  - Neoplasms, Radiation-Induced/metabolism/pathology/*prevention & control
MH  - Nitric Oxide/metabolism
MH  - Radiation-Protective Agents/*pharmacology
MH  - Signal Transduction/drug effects/radiation effects
MH  - Skin Neoplasms/metabolism/pathology/*prevention & control
MH  - Sunburn/pathology
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Ultraviolet Rays/*adverse effects
EDAT- 2011/05/07 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1667/RR2510.1 [pii]
AID - 10.1667/rr2510.1 [doi]
PST - ppublish
SO  - Radiat Res. 2011 Aug;176(2):177-86. doi: 10.1667/rr2510.1. Epub 2011 May 5.