PMID- 21545820
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20110613
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 7
DP  - 2011 Jul
TI  - Human leukocyte antigen class II and type 1 diabetes in Latin America: a combined 
      meta-analysis of association and family-based studies.
PG  - 581-6
LID - 10.1016/j.humimm.2011.03.012 [doi]
AB  - Conclusions from association studies could be spurious because of population 
      stratification; therefore we combined association with family studies seeking to 
      confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were 
      associated with type 1 diabetes (T1D) in the admixed Latin America. By 
      calculating the effect summary odds ratios (OR) and their 95% confidence 
      intervals (95% CI), data up to June 2010 showed that risk associations were 
      observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% 
      confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 
      11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In 
      contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 
      0.91-5.43). T1D protective associations were observed with 
      DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and 
      DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were 
      similar to those observed in Caucasian and other populations, thus highlighting 
      the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk 
      hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction 
      analysis disclosed possible receptor-ligand interactions in the HLA-antigenic 
      peptide complex.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Cifuentes, Ricardo A
AU  - Cifuentes RA
AD  - Center for Autoimmune Diseases Research, School of Medicine and Health Sciences, 
      Universidad del Rosario, Bogota, Colombia. ricardo.cifuentesgarcia@gmail.com
FAU - Rojas-Villarraga, Adriana
AU  - Rojas-Villarraga A
FAU - Anaya, Juan-Manuel
AU  - Anaya JM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20110415
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Peptides)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Computational Biology
MH  - Diabetes Mellitus, Type 1/*genetics/immunology
MH  - Epitopes/chemistry/immunology
MH  - Haplotypes
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Latin America
MH  - Peptides/chemistry/immunology
MH  - Protein Binding/immunology
EDAT- 2011/05/07 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/01/07 00:00 [received]
PHST- 2011/03/31 00:00 [revised]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - S0198-8859(11)00065-6 [pii]
AID - 10.1016/j.humimm.2011.03.012 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Jul;72(7):581-6. doi: 10.1016/j.humimm.2011.03.012. Epub 2011 
      Apr 15.