PMID- 21546243
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20190221
IS  - 1873-4022 (Electronic)
IS  - 1873-4022 (Linking)
VI  - 37
IP  - 2
DP  - 2012 Summer
TI  - Effect of beam arrangement on oral cavity dose in external beam radiotherapy of 
      nasopharyngeal carcinoma.
PG  - 122-6
LID - 10.1016/j.meddos.2011.02.003 [doi]
AB  - This study compared the oral cavity dose between the routine 7-beam 
      intensity-modulated radiotherapy (IMRT) beam arrangement and 2 other 7-beam IMRT 
      with the conventional radiotherapy beam arrangements in the treatment of 
      nasopharyngeal carcinoma (NPC). Ten NPC patients treated by the 7-beam routine 
      IMRT technique (IMRT-7R) between April 2009 and June 2009 were recruited. Using 
      the same computed tomography data, target information, and dose constraints for 
      all the contoured structures, 2 IMRT plans with alternative beam arrangements 
      (IMRT-7M and IMRT-7P) by avoiding the anterior facial beam and 1 conventional 
      radiotherapy plan (CONRT) were computed using the Pinnacle treatment planning 
      system. Dose-volume histograms were generated for the planning target volumes 
      (PTVs) and oral cavity from which the dose parameters and the conformity index of 
      the PTV were recorded for dosimetric comparisons among the plans with different 
      beam arrangements. The dose distributions to the PTVs were similar among the 3 
      IMRT beam arrangements, whereas the differences were significant between IMRT-7R 
      and CONRT plans. For the oral cavity dose, the 3 IMRT beam arrangements did not 
      show significant difference. Compared with IMRT-7R, CONRT plan showed a 
      significantly lower mean dose, V30 and V-40, whereas the V-60 was significantly 
      higher. The 2 suggested alternative beam arrangements did not significantly 
      reduce the oral cavity dose. The impact of varying the beam angles in IMRT of NPC 
      did not give noticeable effect on the target and oral cavity. Compared with IMRT, 
      the 2-D conventional radiotherapy irradiated a greater high-dose volume in the 
      oral cavity.
CI  - Copyright (c) 2012 American Association of Medical Dosimetrists. Published by 
      Elsevier Inc. All rights reserved.
FAU - Wu, Vincent W C
AU  - Wu VW
AD  - Department of Health Technology and Informatics, Hong Kong Polytechnic 
      University, Kowloon, Hong Kong, China.
FAU - Yang, Zhi-Ning
AU  - Yang ZN
FAU - Zhang, Wu-Zhe
AU  - Zhang WZ
FAU - Wu, Li-li
AU  - Wu LL
FAU - Lin, Zhi-xiong
AU  - Lin ZX
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110504
PL  - United States
TA  - Med Dosim
JT  - Medical dosimetry : official journal of the American Association of Medical 
      Dosimetrists
JID - 8908862
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma/*radiotherapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mouth
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/*instrumentation
EDAT- 2011/05/07 06:00
MHDA- 2012/09/12 06:00
CRDT- 2011/05/07 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/12/29 00:00 [revised]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - S0958-3947(11)00059-8 [pii]
AID - 10.1016/j.meddos.2011.02.003 [doi]
PST - ppublish
SO  - Med Dosim. 2012 Summer;37(2):122-6. doi: 10.1016/j.meddos.2011.02.003. Epub 2011 
      May 4.