PMID- 2154722
OWN - NLM
STAT- MEDLINE
DCOM- 19900319
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 108
IP  - 1-2
DP  - 1990 Jan 1
TI  - The effect of repeated treatment with brofaromine, moclobemide and deprenyl on 
      alpha 1-adrenergic and dopaminergic receptors in the rat brain.
PG  - 189-94
AB  - The binding of [3H]prazosin to alpha 1-adrenoreceptors, as well as of [3H]SCH 
      23390 (R(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-o l) 
      to dopamine D1 receptors, and [3H]spiperone to D2 receptors was studied following 
      repeated administration of the monoamine oxidase inhibitors (MAOI) brofaromine, 
      moclobemide and deprenyl to rats. Scatchard analysis showed no change in the 
      density (Bmax) and affinity (Kd) of [3H]prazosin sites, yet the ability of 
      phenylephrine (an alpha 1-adrenoceptor agonist) to compete for [3H]antagonist 
      binding sites was enhanced in the cerebral cortex after repeated brofaromine 
      administration, as well as in the hippocampus of rats pretreated with moclobemide 
      and deprenyl. The density and the binding affinity of dopaminergic D1 and D2 
      receptors were not affected by repeated treatment with all the MAOI used. The 
      results seem to indicate that a small increase in the alpha 1-adrenoceptor 
      agonist affinity occurs after repeated administration of MAOI.
FAU - Klimek, V
AU  - Klimek V
AD  - Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
FAU - Nowak, G
AU  - Nowak G
FAU - Zak, J
AU  - Zak J
FAU - Maj, J
AU  - Maj J
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Benzamides)
RN  - 0 (Phenethylamines)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0 (Receptors, Dopamine)
RN  - 2K1V7GP655 (Selegiline)
RN  - 6WV4B8Q07H (brofaromine)
RN  - PJ0Y7AZB63 (Moclobemide)
RN  - XM03YJ541D (Prazosin)
SB  - IM
MH  - Animals
MH  - Benzamides/*pharmacology
MH  - Brain/drug effects/*metabolism
MH  - Male
MH  - Moclobemide
MH  - Phenethylamines/*pharmacology
MH  - Piperidines/*pharmacology
MH  - Prazosin/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic, alpha/*drug effects
MH  - Receptors, Dopamine/*drug effects
MH  - Selegiline/*pharmacology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 0304-3940(90)90729-S [pii]
AID - 10.1016/0304-3940(90)90729-s [doi]
PST - ppublish
SO  - Neurosci Lett. 1990 Jan 1;108(1-2):189-94. doi: 10.1016/0304-3940(90)90729-s.