PMID- 21547404
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20211020
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 21
IP  - 6
DP  - 2011 Jun
TI  - Is intestinal gluconeogenesis a key factor in the early changes in glucose 
      homeostasis following gastric bypass?
PG  - 759-62
LID - 10.1007/s11695-011-0380-7 [doi]
AB  - BACKGROUND: In 2008, Troy et al. hypothesised that under fasting conditions, 
      intestinal gluconeogenesis generates glucose levels in the portal vein which 
      trigger the portal sensor to change insulin resistance and that this mechanism 
      contributes to the effects of Roux-en-Y gastric bypass (RYGB) surgery on type 2 
      diabetes mellitus (T2DM). In a recent paper, Kashyap et al. (Int J Obes 
      34(3):426-471, 2010) cited this hypothesis as a potential explanation for the 
      early changes in insulin sensitivity and beta cell function seen after RYGB. We 
      proposed a study to examine this possibility. METHODS: We simultaneously sampled 
      fasting portal venous blood and central venous blood in 28 patients (eight 
      diabetics and 20 non-diabetics) before and again six days after RYGB surgery in 
      morbidly obese patients, for measurement of glucose levels. RESULTS: We found no 
      significant difference in the glucose levels from the two sites either before or 
      after RYGB in diabetic patients and a small, but significant difference in the 
      post-operative glucose levels from non-diabetic patients (4.2 vs 4.0 mM, 
      p < 0.0001). CONCLUSIONS: Direct simultaneous measurement of fasting glucose in 
      portal and central venous blood before and 6 days after RYGB provides no evidence 
      to support the hypothesis that intestinal gluconeogenesis contributes to the 
      resolution of T2DM seen after RYGB.
FAU - Hayes, Mark Thomas
AU  - Hayes MT
AD  - Wakefield Biomedical Research Unit, University of Otago, Wellington, New Zealand.
FAU - Foo, Jonathan
AU  - Foo J
FAU - Besic, Vinko
AU  - Besic V
FAU - Tychinskaya, Yulia
AU  - Tychinskaya Y
FAU - Stubbs, Richard Strawson
AU  - Stubbs RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Blood Glucose)
SB  - IM
CIN - Obes Surg. 2012 Dec;22(12):1920-2; author reply 1923-4. PMID: 22961684
MH  - Adult
MH  - Blood Glucose/analysis/*metabolism
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood/surgery
MH  - Female
MH  - *Gastric Bypass
MH  - *Gluconeogenesis
MH  - Homeostasis
MH  - Humans
MH  - Intestinal Mucosa/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/blood/*surgery
MH  - Portal Vein
EDAT- 2011/05/07 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1007/s11695-011-0380-7 [doi]
PST - ppublish
SO  - Obes Surg. 2011 Jun;21(6):759-62. doi: 10.1007/s11695-011-0380-7.