PMID- 21547905
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20220317
IS  - 1096-9896 (Electronic)
IS  - 0022-3417 (Linking)
VI  - 224
IP  - 3
DP  - 2011 Jul
TI  - Talin-1 overexpression defines high risk for aggressive oral squamous cell 
      carcinoma and promotes cancer metastasis.
PG  - 367-76
LID - 10.1002/path.2867 [doi]
AB  - Oral squamous cell carcinoma (OSCC) is highly invasive and is associated with 
      frequent tumour recurrences and lymph node metastases. Identification of genes 
      involved in the aggressiveness of OSCC may provide new targets for clinical 
      intervention. A genome-wide study based on the Sty1 250K SNP array indicated the 
      involvement of the Talin-1 (TLN1) gene in the 9p13.3 amplicon, which was further 
      validated by dual colour fluorescence in situ hybridization (FISH). Comparative 
      analyses revealed that TLN1 was the most highly expressed integrin-cytoskeleton 
      cross-linker that can trigger integrin activation. IHC analyses and mouse study 
      also revealed an association between TLN1 overexpression and advanced OSCC with 
      invasion to adjacent tissues. Survival analyses indicated a significant 
      association between TLN1 genetic gain/overexpression and a reduced overall 
      survival in patients. Functional knockdown by a dominant negative TLN1 fragment 
      reduced cell growth and invasiveness in TLN1-overexpressing cells via 
      inactivation of downstream oncogenic signalling. The present study suggests an 
      important role for TLN1 in oral cancer development. TLN1 overexpression could 
      serve as a diagnostic marker for aggressive phenotypes and a potential target for 
      treating OSCC.
CI  - Copyright (c) 2011 Pathological Society of Great Britain and Ireland. Published by 
      John Wiley & Sons, Ltd.
FAU - Lai, Ming-Tsung
AU  - Lai MT
AD  - Department of Pathology, Chung Shan Medical University Hospital, Taichung, 
      Taiwan.
FAU - Hua, Chun-Hung
AU  - Hua CH
FAU - Tsai, Ming-Hsui
AU  - Tsai MH
FAU - Wan, Lei
AU  - Wan L
FAU - Lin, Ying-Ju
AU  - Lin YJ
FAU - Chen, Chih-Mei
AU  - Chen CM
FAU - Chiu, I-Wen
AU  - Chiu IW
FAU - Chan, Carmen
AU  - Chan C
FAU - Tsai, Fuu-Jen
AU  - Tsai FJ
FAU - Jinn-Chyuan Sheu, Jim
AU  - Jinn-Chyuan Sheu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110505
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (TLN1 protein, human)
RN  - 0 (Talin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology/*secondary
MH  - Cell Division/physiology
MH  - Cell Transformation, Neoplastic/metabolism
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/genetics/*metabolism/pathology
MH  - Neoplasm Invasiveness
MH  - Neoplasm Proteins/biosynthesis/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Survival Analysis
MH  - Talin/*biosynthesis/genetics
MH  - Tumor Cells, Cultured
EDAT- 2011/05/07 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/05/07 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/01/19 00:00 [revised]
PHST- 2011/01/30 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 10.1002/path.2867 [doi]
PST - ppublish
SO  - J Pathol. 2011 Jul;224(3):367-76. doi: 10.1002/path.2867. Epub 2011 May 5.