PMID- 2154832
OWN - NLM
STAT- MEDLINE
DCOM- 19900327
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 100
IP  - 2
DP  - 1990
TI  - ACTH-induced behaviors and their modulation by serotonergic agonists differ in 
      neonatal and weanling rat pups.
PG  - 151-8
AB  - Four-day-old (P4) and 21-22-day-old (P21-22) rat pups received an intracisternal 
      injection of either ACTH1-16NH2 or saline followed by a subcutaneous (SC) 
      injection of saline, the serotonergic (5HT)1A agonists 8-OH-DPAT or ipsapirone, 
      the 5HT1B agonist TFMPP or the 5HT2 agonist DOI. The ontogeny of ACTH-induced 
      behaviors including grooming, yawn and stretch as well as various 
      serotonin-related behaviors were recorded via time-sampling at 20 s intervals for 
      a test duration of 50 min. ACTH induced slight but significant increases in 
      grooming at P4, along with a significant increase in yawning. At this age the 
      5HT1B agonist TFMPP induced substantial increases in grooming, with no effect of 
      the other agonists on this behavior. All of the serotonergic agonists, however, 
      decreased ACTH-induced yawning at P4. At P21-22 ACTH induced more robust grooming 
      than that observed at P4, although different in nature from adult-typical 
      ACTH-induced grooming. This ACTH-induced grooming at P21-22 was attenuated by all 
      of the serotonergic agonists. ACTH-induced yawning at P21-22 was not affected by 
      the serotonergic agonists while ACTH-induced stretching was increased by the 
      5HT1B agonist TFMPP at this age. These data provide additional evidence of 
      differential mediation of various ACTH-induced behaviors, and support other 
      reports of ontogenetic alterations in the response to serotonergic manipulations 
      during the neonatal to weanling age period.
FAU - Kirstein, C L
AU  - Kirstein CL
AD  - State University of New York, Psychology Department, Binghamton 13901.
FAU - Traber, J
AU  - Traber J
FAU - Gispen, W H
AU  - Gispen WH
FAU - Spear, L P
AU  - Spear LP
LA  - eng
GR  - S07 RR07149-13/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 333DO1RDJY (Serotonin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/*pharmacology
MH  - Aging/physiology
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Behavior, Animal/*drug effects/physiology
MH  - Female
MH  - Grooming/drug effects/physiology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*physiology
MH  - Yawning/drug effects
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1007/BF02244398 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1990;100(2):151-8. doi: 10.1007/BF02244398.