PMID- 21549116
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20211020
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 661
IP  - 1-3
DP  - 2011 Jul 1
TI  - Behavioral sensitization and cross-sensitization between methylphenidate 
      amphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) in female SD rats.
PG  - 72-85
LID - 10.1016/j.ejphar.2011.04.035 [doi]
AB  - The psychostimulants amphetamine and methylphenidate (MPD/Ritalin) are the drugs 
      most often used to treat attention deficit hyperactivity disorder (ADHD). In 
      addition, students of all ages take these drugs to improve academic performance 
      but also abuse them for pleasurable enhancement. In addition, other 
      psychostimulants such as 3,4-methylenedioxymethamphetamine (MDMA/ecstasy) are 
      used/abused for similar objectives. One of the experimental markers for the 
      potential of a drug to produce dependence is its ability to induce behavioral 
      sensitization and cross sensitization with other drugs of abuse. The objective of 
      this study is to use identical experimental protocols and behavioral assays to 
      compare in female rats the effects of amphetamine, MPD and MDMA on locomotor 
      activity and to determine if they induce behavioral sensitization and/or cross 
      sensitization with each other. The main findings of this study are as follows: 
      (1) acute amphetamine, MPD and MDMA all elicited increases in locomotor activity; 
      (2) chronic administration of an intermediate dose of amphetamine or MPD elicited 
      behavioral sensitization; (3) chronic administration of MDMA elicited behavioral 
      sensitization in some animals and behavioral tolerance in others; (4) cross 
      sensitization between MPD and amphetamine was observed; and (5) MDMA did not show 
      either cross sensitization or cross tolerance with amphetamine. In conclusion, 
      these results suggest that MDMA acts by different mechanisms compared to MPD and 
      amphetamine.
CI  - Copyright (c) 2011. Published by Elsevier B.V.
FAU - Yang, Pamela B
AU  - Yang PB
AD  - Department of Anatomy and Neurobiology, University of California, Irvine-School 
      of Medicine, 92697, United States.
FAU - Atkins, Kristal D
AU  - Atkins KD
FAU - Dafny, Nachum
AU  - Dafny N
LA  - eng
GR  - F31 DA014441/DA/NIDA NIH HHS/United States
GR  - R01 DA027222/DA/NIDA NIH HHS/United States
GR  - F31 DA 14441/DA/NIDA NIH HHS/United States
GR  - R01-DA 027222/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110428
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Drug Interactions
MH  - Drug Tolerance
MH  - Female
MH  - Methylphenidate/administration & dosage/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
PMC - PMC4036816
MID - NIHMS299273
EDAT- 2011/05/10 06:00
MHDA- 2011/09/21 06:00
PMCR- 2014/05/28
CRDT- 2011/05/10 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2011/04/08 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
PHST- 2014/05/28 00:00 [pmc-release]
AID - S0014-2999(11)00444-4 [pii]
AID - 10.1016/j.ejphar.2011.04.035 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2011 Jul 1;661(1-3):72-85. doi: 10.1016/j.ejphar.2011.04.035. 
      Epub 2011 Apr 28.