PMID- 21549295
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20110509
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 17
IP  - 5
DP  - 2011 May
TI  - Myocardial blood flow and fibrosis in hypertrophic cardiomyopathy.
PG  - 384-91
LID - 10.1016/j.cardfail.2011.01.006 [doi]
AB  - BACKGROUND: We investigated the relationship between myocardial blood flow (MBF), 
      fibrosis, risk factors for sudden death, and clinical manifestations in 
      hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: Sixty-two patients with 
      HCM (45 men, overall mean age 47 +/- 16 years), 15 acromegalic patients with left 
      ventricular hypertrophy (9 man, overall mean age 47 +/- 12 years), and 20 healthy 
      subjects underwent cardiac magnetic resonance. Resting MBF was measured as the 
      ratio between coronary sinus flow measured by phase-contrast technique and left 
      ventricular mass. Myocardial fibrosis was evaluated by late gadolinium 
      enhancement (LGE) technique. In HCM patients, MBF was significantly lower than in 
      control subjects and acromegalic patients. Patients with LGE had lower MBF than 
      those without it (0.46 +/- 0.2 vs 0.66 +/- 0.29 mL.min(-1).g(-1); P < .005). Patients 
      with ventricular tachycardia at Holter monitoring had lower MBF (0.4 +/- 0.14 vs 
      0.6 +/- 0.29 mL.min(-1).g(-1); P < .04). Among patients with preserved systolic 
      function, those in New York Heart Association (NYHA) functional class >/=II had 
      lower MBF than those in NYHA functional class I (0.46 +/- 0.2 vs 0.69 +/- 0.3 
      mL.min(-1).g(-1); P < .003). MBF was the only independent predictor of worse 
      clinical status (NYHA >/=II; P = .01). CONCLUSIONS: In HCM patients low resting MBF 
      is associated with the presence of fibrosis. MBF is a predictor of worse clinical 
      status.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy. aquaro@ifc.cnr.it
FAU - Todiere, Giancarlo
AU  - Todiere G
FAU - Barison, Andrea
AU  - Barison A
FAU - Strata, Elisabetta
AU  - Strata E
FAU - Marzilli, Mario
AU  - Marzilli M
FAU - Pingitore, Alessandro
AU  - Pingitore A
FAU - Lombardi, Massimo
AU  - Lombardi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110226
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Adult
MH  - Blood Flow Velocity/*physiology
MH  - Cardiomyopathy, Hypertrophic/*pathology/physiopathology
MH  - Coronary Vessels/*pathology/physiology
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
EDAT- 2011/05/10 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/05/10 06:00
PHST- 2010/09/09 00:00 [received]
PHST- 2011/01/12 00:00 [revised]
PHST- 2011/01/19 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - S1071-9164(11)00021-2 [pii]
AID - 10.1016/j.cardfail.2011.01.006 [doi]
PST - ppublish
SO  - J Card Fail. 2011 May;17(5):384-91. doi: 10.1016/j.cardfail.2011.01.006. Epub 
      2011 Feb 26.