PMID- 21549440
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20161125
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 99
IP  - 2
DP  - 2011 May
TI  - Comparison of the planning target volume based on three-dimensional CT and 
      four-dimensional CT images of non-small-cell lung cancer.
PG  - 176-80
LID - 10.1016/j.radonc.2011.03.015 [doi]
AB  - BACKGROUND AND PURPOSE: To compare positional and volumetric differences of 
      planning target volumes (PTVs) based on axial three-dimensional CT (3DCT) and 
      four-dimensional CT (4DCT) for the primary tumor of non-small cell lung cancer 
      (NSCLC). MATERIALS AND METHODS: Twenty-eight patients with NSCLC underwent 3DCT 
      and 4DCT scans of the thorax during normal free breathing. PTV(vector) was 
      defined on 3DCT using the individual tumor motion vector measured by 4DCT 
      accounting for tumor motion; PTV(4D) was defined on all phases of 4DCT images. In 
      addition, a 7mm margin for microscopic disease and a 3mm setup margin were used 
      for above PTVs, respectively. The differences in target position, volume and 
      coverage between PTV(vector) and PTV(4D) were evaluated for tumors in different 
      lobes, respectively. RESULTS: The median motion vector for tumors located in the 
      upper lobe (group A) and in the middle lower lobe (group B) was 2.8 and 7mm, 
      respectively. The mean centroid shifts between PTV(vector) and PTV(4D) in the LR, 
      AP and CC directions for group A and B were close to zero. The median size ratio 
      of PTV(4D) to PTV(vector) was 0.75 and 0.52 for group A and B. The motion vector 
      showed a significant correlation to the ratio of PTV(4D) to PTV(vector) for group 
      A and B (p=0.008 and 0.003). The median DI of PTV(vector) in PTV(4D) was 69.19% 
      for group A and 51.60% for group B. The median DI of PTV(4D) in PTV(vector) was 
      98.99% for group A and 99.94% for group B. CONCLUSION: It is necessary to expand 
      the internal margin isotropically in a single direction for 3DCT treatment 
      planning due to the uncertainty of the 3DCT-based target position. The 3DCT-based 
      PTV using individual margins provides a good coverage of the 4DCT-based PTV, 
      meanwhile encompasses relatively large normal tissues, especially for middle and 
      lower lobe tumors. We should be cautious about the use of the individual PTV 
      derived from 3DCT in treatment planning.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Li, Feng Xiang
AU  - Li FX
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, 
      China.
FAU - Li, Jian Bin
AU  - Li JB
FAU - Zhang, Ying Jie
AU  - Zhang YJ
FAU - Liu, Tong Hai
AU  - Liu TH
FAU - Tian, Shi Yu
AU  - Tian SY
FAU - Xu, Min
AU  - Xu M
FAU - Shang, Dong Ping
AU  - Shang DP
FAU - Ma, Chang Sheng
AU  - Ma CS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110504
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic 
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging
MH  - Female
MH  - *Four-Dimensional Computed Tomography
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Lung Neoplasms/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Movement
MH  - Patient Positioning
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Respiration
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/05/10 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/05/10 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/03/08 00:00 [revised]
PHST- 2011/03/27 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0167-8140(11)00170-8 [pii]
AID - 10.1016/j.radonc.2011.03.015 [doi]
PST - ppublish
SO  - Radiother Oncol. 2011 May;99(2):176-80. doi: 10.1016/j.radonc.2011.03.015. Epub 
      2011 May 4.