PMID- 21549694
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 662
IP  - 1-3
DP  - 2011 Jul 15
TI  - Embelin reduces cutaneous TNF-alpha level and ameliorates skin edema in acute and 
      chronic model of skin inflammation in mice.
PG  - 63-9
LID - 10.1016/j.ejphar.2011.04.037 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is known to play a crucial role in the 
      pathogenesis of psoriasis. The present study was designed to investigate the 
      effects of embelin on lipopolysachharide induced TNF-alpha production in mice and in 
      human keratinocytes in vitro and also to study the effect of embelin on acute and 
      chronic skin inflammation in mice. Production of pro-inflammatory cytokines 
      (TNF-alpha and IL-1beta), activation of myeloperoxidase and histological assessment were 
      examined in acute and chronic skin inflammation using 
      12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema. Embelin 
      inhibited topical edema in the mouse ear, leading to substantial reductions in 
      skin thickness and tissue weight, inflammatory cytokine production, 
      neutrophil-mediated myeloperoxidase activity, and various histopathological 
      indicators. Furthermore, embelin was effective at reducing inflammatory damage 
      induced by chronic TPA exposure. Our data indicate that embelin has 
      anti-inflammatory activities in both acute and chronic irritant contact 
      dermatitis in vivo and this effect of embelin may be due, at least in part, to 
      the inhibition of IL-1beta and TNF-alpha and to the subsequent blockade of leukocyte 
      accumulation.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Kalyan Kumar, G
AU  - Kalyan Kumar G
AD  - Post-Graduate Research Center, Department of Plant Biology and Biotechnology, 
      Presidency College, Chennai, Tamil Nadu, India. kalyanmicro@hotmail.com
FAU - Dhamotharan, R
AU  - Dhamotharan R
FAU - Kulkarni, Nagaraj M
AU  - Kulkarni NM
FAU - Mahat, Mahamad Yunnus A
AU  - Mahat MY
FAU - Gunasekaran, J
AU  - Gunasekaran J
FAU - Ashfaque, Mohammad
AU  - Ashfaque M
LA  - eng
PT  - Journal Article
DEP - 20110430
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Benzoquinones)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
RN  - SHC6U8F5ER (embelin)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Animals
MH  - Benzoquinones/chemistry/*pharmacology/therapeutic use
MH  - Chronic Disease
MH  - Cytokines/biosynthesis
MH  - Disease Models, Animal
MH  - Ear Diseases/chemically induced/drug therapy/metabolism
MH  - Edema/chemically induced/*drug therapy/*metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/chemically induced/drug therapy/metabolism
MH  - Keratinocytes/drug effects/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Skin Diseases/chemically induced/*drug therapy/*metabolism
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Tumor Necrosis Factor-alpha/biosynthesis/*metabolism
EDAT- 2011/05/10 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/10 06:00
PHST- 2010/11/20 00:00 [received]
PHST- 2011/03/31 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0014-2999(11)00446-8 [pii]
AID - 10.1016/j.ejphar.2011.04.037 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9. doi: 10.1016/j.ejphar.2011.04.037. 
      Epub 2011 Apr 30.