PMID- 21549809
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20161125
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 498
IP  - 1
DP  - 2011 Jul 1
TI  - Respiratory responses to somatostatin microinjections into the Botzinger complex 
      and the pre-Botzinger complex of the rabbit.
PG  - 26-30
LID - 10.1016/j.neulet.2011.04.054 [doi]
AB  - The respiratory responses to bilateral microinjections (30-50 nl) of 5mM 
      somatostatin (SOM) or 10mM cyclosomatostatin (c-SOM, a SOM antagonist) into the 
      Botzinger complex (BotC), the pre-Botzinger complex (preBotC) and the rostral 
      inspiratory portion of the ventral respiratory group (iVRG) were investigated in 
      urethane-chloralose anesthetized, vagotomized, paralysed and artificially 
      ventilated rabbits. SOM microinjections into the BotC decreased respiratory 
      frequency and the rate of rise of phrenic nerve activity without obvious changes 
      in its peak amplitude. SOM microinjected into the preBotC caused increases in 
      respiratory frequency and decreases in peak phrenic activity associated with 
      increases in its rate of rise. No changes in respiration were induced by SOM 
      microinjections into the iVRG. Microinjections of c-SOM into the preBotC caused 
      decreases in respiratory frequency as well as in peak amplitude and rate of rise 
      of phrenic nerve activity. The results show that endogenously released SOM within 
      the preBotC contributes to shape the pattern of baseline respiratory activity and 
      that SOM receptors within the BotC and the preBotC have a role in the modulation 
      of respiration in the rabbit.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Pantaleo, Tito
AU  - Pantaleo T
AD  - Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale 
      G.B. Morgagni 63, I-50134 Firenze, Italy. tito.pantaleo@unifi.it
FAU - Mutolo, Donatella
AU  - Mutolo D
FAU - Cinelli, Elenia
AU  - Cinelli E
FAU - Bongianni, Fulvia
AU  - Bongianni F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110428
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Hormones)
RN  - 51110-01-1 (Somatostatin)
SB  - IM
MH  - Animals
MH  - Hormones/*administration & dosage/metabolism
MH  - Injections, Intraventricular
MH  - Microinjections
MH  - Phrenic Nerve/drug effects/physiology
MH  - Rabbits
MH  - Respiratory Center/*drug effects/*physiology
MH  - Respiratory Physiological Phenomena/*drug effects
MH  - Somatostatin/*administration & dosage/metabolism
EDAT- 2011/05/10 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/04/20 00:00 [revised]
PHST- 2011/04/21 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - S0304-3940(11)00526-X [pii]
AID - 10.1016/j.neulet.2011.04.054 [doi]
PST - ppublish
SO  - Neurosci Lett. 2011 Jul 1;498(1):26-30. doi: 10.1016/j.neulet.2011.04.054. Epub 
      2011 Apr 28.