PMID- 21550050
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20220318
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 45
IP  - 8
DP  - 2011 Aug
TI  - Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar 
      disorders: a systematic review and meta-regression analysis.
PG  - 995-1004
LID - 10.1016/j.jpsychires.2011.03.002 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays a central role in synaptic 
      plasticity and neurogenesis. Bipolar disorder (BD) is among the most disabling of 
      all psychiatric disorders and is associated with poor outcomes. Some studies 
      suggest that BDNF levels decrease during mood states and remain normal during 
      euthymia, but other studies have contradicted this paradigm. Therefore, the aim 
      of this study was to perform a meta-analysis of all studies that measured 
      peripheral BDNF levels in adults with BD. We conducted a systematic review using 
      electronic databases. Inclusion criteria were studies that measured BDNF in 
      plasma or serum in vivo in adult patients with BD. The resulting studies were 
      compiled to measure the effect sizes (ESs) of the differences in BDNF levels 
      between BD patients in different mood states and controls. Thirteen studies were 
      included with a total of 1113 subjects. The BDNF levels were decreased in both 
      mania and depression when compared to controls (ES -0.81, 95% CI -1.11 to -0.52, 
      p < 0.0001 and ES -0.97, 95% CI -1.79 to -0.51, p = 0.02, respectively). The BDNF 
      levels were not different in euthymia when compared to controls (ES -0.20, 95% 
      CI -0.61 to 0.21, p = 0.33). Meta-regression analyses in euthymia showed that age 
      (p < 0.0001) and length of illness (p = 0.04) influenced the variation in ES. 
      There was also an increase in BDNF levels following the treatment for acute mania 
      (ES -0.63, 95% CI -1.11 to -0.15, p = 0.01). In conclusion, BDNF levels are 
      consistently reduced during manic and depressive episodes and recover after 
      treatment for acute mania. In euthymia, BDNF decreases with age and length of 
      illness. These data suggest that peripheral BDNF could be used as a biomarker of 
      mood states and disease progression for BD.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Fernandes, Brisa Simoes
AU  - Fernandes BS
AD  - Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      Brazil. brisasf@gmail.com
FAU - Gama, Clarissa Severino
AU  - Gama CS
FAU - Cereser, Keila Maria
AU  - Cereser KM
FAU - Yatham, Lakshmi N
AU  - Yatham LN
FAU - Fries, Gabriel Rodrigo
AU  - Fries GR
FAU - Colpo, Gabriela
AU  - Colpo G
FAU - de Lucena, David
AU  - de Lucena D
FAU - Kunz, Mauricio
AU  - Kunz M
FAU - Gomes, Fabiano Alves
AU  - Gomes FA
FAU - Kapczinski, Flavio
AU  - Kapczinski F
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110506
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Antidepressive Agents/therapeutic use
MH  - Bipolar Disorder/*blood/classification/diagnosis/drug therapy
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Databases, Factual/statistics & numerical data
MH  - Humans
MH  - Regression Analysis
EDAT- 2011/05/10 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/10 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2011/02/20 00:00 [revised]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0022-3956(11)00041-0 [pii]
AID - 10.1016/j.jpsychires.2011.03.002 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2011 Aug;45(8):995-1004. doi: 10.1016/j.jpsychires.2011.03.002. 
      Epub 2011 May 6.