PMID- 21554252
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Jul
TI  - MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans.
PG  - 38-44
LID - 10.1111/j.1399-0039.2011.01694.x [doi]
AB  - Major histocompatibility complex (MHC) class I chain-related gene B (MICB) is 
      located within the human MHC class I region. The location of MICB in the MHC 
      region may imply the presence of linkage disequilibrium with polymorphic MICA and 
      human leukocyte antigen (HLA) loci. MICB is also polymorphic; however, MICB 
      polymorphisms have not been investigated in Koreans. Using sequence-based typing 
      (SBT), we estimated the allelic frequencies of MICB and haplotypes with MICA, 
      HLA-B, and HLA-DRB1 at high resolution in a population of 139 unrelated Korean 
      individuals. Eight MICB alleles were identified. The most frequent allele was 
      MICB*005:02/*010 (57.2%), followed by *002 (11.5%), *004 (8.3%), *005:03 (8.3%), 
      and *008 (6.8%). The most common two-locus haplotypes were 
      MICB*005:02/*010-MICA*010 (19.4%), MICB*005:02/*010-DRB1*15:01 (6.5%), and 
      MICB*005:02/*010-B*15:01 (10.4%); the most common three-locus haplotypes were 
      B*15:01-MICA*010-MICB*005:02/*010 (5.8%) and MICA*010-MICB*005:02/*010-DRB1*04:06 
      (10.4%); and the most common four-locus haplotype was 
      B*15:01-MICA*010-MICB*005:02/*010-DRB1*04:06 (5.8%). This is the first study to 
      provide information about MICB allele frequencies and haplotypes with HLA in 
      Koreans. These study results should help understand mechanisms of disease 
      association between the MICB locus and neighboring loci in Koreans.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Cha, C-H
AU  - Cha CH
AD  - Department of Laboratory Medicine, Gangneung Asan Hospital, University of Ulsan 
      College of Medicine, Gangneung, South Korea.
FAU - Sohn, Y-H
AU  - Sohn YH
FAU - Oh, H-B
AU  - Oh HB
FAU - Ko, S-Y
AU  - Ko SY
FAU - Cho, M-C
AU  - Cho MC
FAU - Kwon, O-J
AU  - Kwon OJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110510
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (MICB antigen)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Ethnicity/genetics
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Korea
MH  - Linkage Disequilibrium
MH  - *Polymorphism, Genetic
EDAT- 2011/05/11 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01694.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Jul;78(1):38-44. doi: 10.1111/j.1399-0039.2011.01694.x. 
      Epub 2011 May 10.