PMID- 21555145
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20181201
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 84
IP  - 3
DP  - 2011 Jun
TI  - Fish consumption reduces transfer of BDE47 from dam to murine offspring.
PG  - 348-54
LID - 10.1016/j.chemosphere.2011.04.004 [doi]
AB  - Fish and seafood are important contributions to a healthy diet, but also contain 
      persistent organic pollutants (POPs) like polybrominated diphenylethers (PBDEs) 
      and polychlorinated biphenyls (PCBs). Discrepancies have been found between 
      intake and accumulated levels of POPs, where fish consumers have had similar 
      levels of POPs to the general population. Similarly fish oil consumption has been 
      found to reduce accumulation of POPs. This study examined the accumulation of 
      BDE47 or PCB153 in mice fed diets with different nutritional composition, using 
      female mice with pre-weanling pups exposed through gestation and lactation. A 
      fish-based diet was compared to a standard casein-based rodent diet. All diets 
      had low background levels of environmental contaminants and were spiked with 
      BDE47 or PCB153 to levels representing a realistic ( approximately 0.004 mumol kg bw(-1) d) or a 
      high dietary exposure ( approximately 1.3 mumol kg bw(-1) d). Accumulation of BDE47 or PCB153 in 
      offspring tissues after 18d lactation reflected the maternal exposure levels. 
      However, the pups of dams fed a fish-based diet had consistently lower BDE47 
      accumulation in liver, fat and stomach than pups from casein-fed dams. Similarly 
      the pups of dams fed a high dose of PCB153 in a fish diet also accumulated less 
      PCB153 than pups of the dams fed a casein diet, although not significant. In 
      conclusion, the fish based diets seemed to reduce transfer of BDE47 and PCB153 
      from dams to pups. The study highlights that in-depth knowledge about nutritional 
      impact on toxicokinetics is of great interest to vulnerable consumers.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Haave, Marte
AU  - Haave M
AD  - National Institute of Nutrition and Seafood Research (NIFES), P.O. Box 2029 
      Nordnes, N-5817 Bergen, Norway. mha@nifes.no
FAU - Bernhard, Annette
AU  - Bernhard A
FAU - Folven, Kristin I
AU  - Folven KI
FAU - Brattelid, Trond
AU  - Brattelid T
FAU - Lundebye, Anne-Katrine
AU  - Lundebye AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110508
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Diet/*methods/statistics & numerical data
MH  - Environmental Pollutants/*metabolism
MH  - Female
MH  - *Fishes
MH  - Gastric Mucosa/metabolism
MH  - Halogenated Diphenyl Ethers
MH  - Humans
MH  - Liver/metabolism
MH  - *Maternal Exposure
MH  - Mice
MH  - Polybrominated Biphenyls/*metabolism
EDAT- 2011/05/11 06:00
MHDA- 2011/09/20 06:00
CRDT- 2011/05/11 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2011/03/08 00:00 [revised]
PHST- 2011/04/01 00:00 [accepted]
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
AID - S0045-6535(11)00395-X [pii]
AID - 10.1016/j.chemosphere.2011.04.004 [doi]
PST - ppublish
SO  - Chemosphere. 2011 Jun;84(3):348-54. doi: 10.1016/j.chemosphere.2011.04.004. Epub 
      2011 May 8.