PMID- 2155554
OWN - NLM
STAT- MEDLINE
DCOM- 19900406
LR  - 20121115
IS  - 0003-0805 (Print)
IS  - 0003-0805 (Linking)
VI  - 141
IP  - 3
DP  - 1990 Mar
TI  - Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid.
PG  - 546-51
AB  - Hydroxymethanesulfonate (HMSA), the bisulfite (HSO3-) adduct of formaldehyde 
      (CH2O), is a common constituent of California acid fogs. HMSA, most stable in a 
      fog pH range of 3 to 5, dissociates at 6.6, the pH of the fluid lining human 
      airways. The dissociation of inhaled HMSA should theoretically generate sulfur 
      dioxide and CH2O, both of which have bronchoconstrictor potential. Thus, we 
      hypothesized that HMSA may have a specific bronchoconstrictor effect independent 
      of its strength as an acid. To determine whether HMSA has such an effect, 19 
      subjects with mild to moderate asthma were studied using two different protocols. 
      Initially, a mouthpiece study was performed in which 9 subjects, on 2 separate 
      days, inhaled five aerosols containing either sequentially increasing 
      concentrations (0, 30, 100, 300, and 1000 microM) of HMSA in 50 microM sulfuric 
      acid (H2SO4) or 50 microM H2SO4 alone. The subjects inhaled each aerosol for 3 
      min during tidal breathing at rest. Specific airway resistance (SRaw) was 
      measured before and after each 3-min exposure. There were no significant 
      differences in the mean changes in SRaw among the various aerosol exposures. To 
      confirm this lack of bronchoconstrictor effect of HMSA, we then performed a 
      chamber study in which 10 freely breathing, intermittently exercising subjects 
      were exposed to fog containing either 1 mM HMSA in 5 mM H2SO4 or 5 mM H2SO4 alone 
      for 1 h. SRaw was measured before, during, and at the end of the 1-h 
      exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Aris, R
AU  - Aris R
AD  - Lung Biology Center, San Francisco General Hospital, CA 94110.
FAU - Christian, D
AU  - Christian D
FAU - Sheppard, D
AU  - Sheppard D
FAU - Balmes, J R
AU  - Balmes JR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Rev Respir Dis
JT  - The American review of respiratory disease
JID - 0370523
RN  - 0 (Air Pollutants)
RN  - 0 (Mesylates)
RN  - 0 (Sulfuric Acids)
RN  - 75-92-3 (formaldehyde bisulfite)
RN  - O40UQP6WCF (sulfuric acid)
SB  - IM
MH  - Administration, Inhalation
MH  - Adult
MH  - Air Pollutants/*adverse effects
MH  - Air Pollution/*adverse effects
MH  - Airway Resistance/drug effects
MH  - Asthma/physiopathology
MH  - Bronchi/drug effects
MH  - Bronchial Diseases/*chemically induced
MH  - Constriction, Pathologic/chemically induced
MH  - Female
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Mesylates/administration & dosage/*adverse effects
MH  - Sulfuric Acids/adverse effects
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 10.1164/ajrccm/141.3.546 [doi]
PST - ppublish
SO  - Am Rev Respir Dis. 1990 Mar;141(3):546-51. doi: 10.1164/ajrccm/141.3.546.