PMID- 21555609
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220409
IS  - 1538-3601 (Electronic)
IS  - 0003-9950 (Linking)
VI  - 129
IP  - 5
DP  - 2011 May
TI  - Retinal pigment epithelium tears secondary to age-related macular degeneration: a 
      simultaneous confocal scanning laser ophthalmoscopy and spectral-domain optical 
      coherence tomography study.
PG  - 575-9
LID - 10.1001/archophthalmol.2011.105 [doi]
AB  - OBJECTIVE: To describe the morphology of retinal pigment epithelium (RPE) tears 
      secondary to age-related macular degeneration by using high-resolution, 
      spectral-domain optical coherence tomography (SD-OCT). METHODS: For simultaneous 
      topographic and tomographic in vivo imaging, confocal scanning laser 
      ophthalmoscopy and spectral-domain optical coherence tomography were applied in 
      combination. Retina over the RPE-denuded area was particularly examined for signs 
      of viable photoreceptors. RESULTS: A total of 26 patients (28 eyes) were included 
      in the study. The mean (SD) age of patients was 78 (8) years (age range, 62-91 
      years). In cases with recent RPE tears, external limiting membrane, photoreceptor 
      inner and outer segment junction, and nonatrophic outer nuclear layer could be 
      identified in the retina on the RPE-denuded area. Intact external limiting 
      membrane, photoreceptor inner and outer segment junction, and nonatrophic outer 
      nuclear layer could be seen in 1 patient for up to 325 days after the RPE tear. 
      In fibrotic older RPE tears, these structures were atrophic. CONCLUSIONS: In this 
      study, signs for viable photoreceptors could be identified for up to 325 days 
      after an RPE tear using spectral-domain optical coherence tomography. This 
      finding is important to consider in future therapies aimed at rescuing 
      photoreceptors after RPE tears.
FAU - Caramoy, Albert
AU  - Caramoy A
AD  - Center of Ophthalmology, Department of Vitreoretinal Surgery, University of 
      Cologne, Kerpenerstr 62, 50924 Cologne, Germany. acaramoy@yahoo.co.uk
FAU - Kirchhof, Bernd
AU  - Kirchhof B
FAU - Fauser, Sascha
AU  - Fauser S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Ophthalmol
JT  - Archives of ophthalmology (Chicago, Ill. : 1960)
JID - 7706534
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Survival
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Macular Degeneration/*complications
MH  - Male
MH  - Microscopy, Confocal
MH  - Middle Aged
MH  - Photoreceptor Cells, Vertebrate/pathology
MH  - Retinal Perforations/diagnosis/*etiology
MH  - Retinal Pigment Epithelium/*pathology
MH  - *Tomography, Optical Coherence
EDAT- 2011/05/11 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 129/5/575 [pii]
AID - 10.1001/archophthalmol.2011.105 [doi]
PST - ppublish
SO  - Arch Ophthalmol. 2011 May;129(5):575-9. doi: 10.1001/archophthalmol.2011.105.